HCSGD entry for ALDH1A1
1. General information
| Official gene symbol | ALDH1A1 |
|---|---|
| Entrez ID | 216 |
| Gene full name | aldehyde dehydrogenase 1 family, member A1 |
| Other gene symbols | ALDC ALDH-E1 ALDH1 ALDH11 PUMB1 RALDH1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001758 | Retinal dehydrogenase activity | IEA | molecular_function |
| GO:0004029 | Aldehyde dehydrogenase (NAD) activity | EXP | molecular_function |
| GO:0005099 | Ras GTPase activator activity | TAS | molecular_function |
| GO:0005497 | Androgen binding | TAS | molecular_function |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006069 | Ethanol oxidation | TAS | biological_process |
| GO:0006081 | Cellular aldehyde metabolic process | TAS | biological_process |
| GO:0006805 | Xenobiotic metabolic process | TAS | biological_process |
| GO:0016491 | Oxidoreductase activity | IEA | molecular_function |
| GO:0032320 | Positive regulation of Ras GTPase activity | TAS | biological_process |
| GO:0042572 | Retinol metabolic process | IEA | biological_process |
| GO:0043085 | Positive regulation of catalytic activity | TAS | biological_process |
| GO:0043547 | Positive regulation of GTPase activity | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0050790 | Regulation of catalytic activity | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8815361232 | 0.0072210934 | 0.9999902473 | 0.1698537980 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.5641273519 |
| GSE13712_SHEAR | Down | -4.7278817233 |
| GSE13712_STATIC | Down | -1.8908588351 |
| GSE19018 | Up | 0.0248840046 |
| GSE19899_A1 | Up | 0.2521782202 |
| GSE19899_A2 | Up | 0.0614770946 |
| PubMed_21979375_A1 | Down | -0.1252992507 |
| PubMed_21979375_A2 | Down | -0.1846136737 |
| GSE35957 | Up | 0.0863989291 |
| GSE36640 | Up | 0.6525031400 |
| GSE54402 | Down | -0.0585300650 |
| GSE9593 | Down | -0.1663063142 |
| GSE43922 | Up | 0.0138019784 |
| GSE24585 | Up | 0.1059264109 |
| GSE37065 | Down | -0.0224942758 |
| GSE28863_A1 | Down | -0.8132147334 |
| GSE28863_A2 | Down | -1.1863081562 |
| GSE28863_A3 | Down | -0.1494145619 |
| GSE28863_A4 | Up | 0.0344240540 |
| GSE48662 | Up | 0.0587769669 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| NADH | DB00157 | NUTR00041 | DB01907 | EXPT02287 | DB03527 |
| Vitamin A | DB00162 | NUTR00007 | APRD00486 |
| 1,4-Dithiothreitol | DB04447 | EXPT01291 |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25279549 | The BORIS-positive cells isolated using BORIS-molecular beacon, expressed higher telomerase hTERT, stem cell (NANOG, OCT4, SOX2) and cancer stem cell marker genes (CD44 and ALDH1) compared to the BORIS-negative tumor cells |
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