HCSGD entry for F10
1. General information
| Official gene symbol | F10 |
|---|---|
| Entrez ID | 2159 |
| Gene full name | coagulation factor X |
| Other gene symbols | FX FXA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004252 | Serine-type endopeptidase activity | IDA IEA TAS | molecular_function |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005543 | Phospholipid binding | IDA | molecular_function |
| GO:0005576 | Extracellular region | IEA NAS TAS | cellular_component |
| GO:0005788 | Endoplasmic reticulum lumen | TAS | cellular_component |
| GO:0005796 | Golgi lumen | TAS | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006508 | Proteolysis | IEA TAS | biological_process |
| GO:0007596 | Blood coagulation | IC TAS | biological_process |
| GO:0007597 | Blood coagulation, intrinsic pathway | TAS | biological_process |
| GO:0007598 | Blood coagulation, extrinsic pathway | TAS | biological_process |
| GO:0017187 | Peptidyl-glutamic acid carboxylation | TAS | biological_process |
| GO:0030335 | Positive regulation of cell migration | TAS | biological_process |
| GO:0031233 | Intrinsic component of external side of plasma membrane | IC | cellular_component |
| GO:0043687 | Post-translational protein modification | TAS | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0051897 | Positive regulation of protein kinase B signaling | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9135448919 | 0.0305416208 | 0.9999902473 | 0.3301379877 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0283371831 |
| GSE13712_SHEAR | Down | -0.0493393476 |
| GSE13712_STATIC | Down | -0.2204018624 |
| GSE19018 | Up | 0.0739442568 |
| GSE19899_A1 | Down | -0.4391099828 |
| GSE19899_A2 | Down | -0.6347816547 |
| PubMed_21979375_A1 | Down | -0.8355508207 |
| PubMed_21979375_A2 | Down | -0.7889199936 |
| GSE35957 | Up | 0.1110365129 |
| GSE36640 | Up | 0.2671643184 |
| GSE54402 | Down | -1.6662540380 |
| GSE9593 | Up | 0.1470723962 |
| GSE43922 | Down | -1.4943599781 |
| GSE24585 | Up | 0.0494370809 |
| GSE37065 | Up | 0.0636287995 |
| GSE28863_A1 | Down | -0.1661082909 |
| GSE28863_A2 | Down | -0.0913186157 |
| GSE28863_A3 | Up | 0.0008800847 |
| GSE28863_A4 | Up | 0.2591310446 |
| GSE48662 | Up | 0.2615134122 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT016852 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26474459 | Finally, we show that the macrophage-dependent induction of PAR-1 driven TGF-beta activation was mediated by FXa |
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