HCSGD entry for F3

1. General information

Official gene symbolF3
Entrez ID2152
Gene full namecoagulation factor III (thromboplastin, tissue factor)
Other gene symbolsCD142 TF TFA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001938Positive regulation of endothelial cell proliferationIDAbiological_process
GO:0002020Protease bindingIPImolecular_function
GO:0002541Activation of plasma proteins involved in acute inflammatory responseIDAbiological_process
GO:0002543Activation of blood coagulation via clotting cascadeICbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005543Phospholipid bindingIDAmolecular_function
GO:0005615Extracellular spaceIDAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processIDAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0007598Blood coagulation, extrinsic pathwayTASbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0010641Positive regulation of platelet-derived growth factor receptor signaling pathwayIDAbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0030335Positive regulation of cell migrationTASbiological_process
GO:0031012Extracellular matrixIDAcellular_component
GO:0031233Intrinsic component of external side of plasma membraneICcellular_component
GO:0045766Positive regulation of angiogenesisIDAbiological_process
GO:0050927Positive regulation of positive chemotaxisICbiological_process
GO:0051897Positive regulation of protein kinase B signalingIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.07624146120.04403643480.58420713250.3946486210

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.5780616669
GSE13712_SHEARUp0.0288806319
GSE13712_STATICDown-0.0346269402
GSE19018Down-0.0323139224
GSE19899_A1Up0.0978559146
GSE19899_A2Up0.5036446576
PubMed_21979375_A1Up0.0833252668
PubMed_21979375_A2Up0.9389069911
GSE35957Up1.6536318515
GSE36640Up0.4504361239
GSE54402Down-0.5640155608
GSE9593Up0.3414105465
GSE43922Up0.6968382774
GSE24585Up0.0460094309
GSE37065Up0.2850996547
GSE28863_A1Down-1.7680818952
GSE28863_A2Up0.3833197163
GSE28863_A3Down-0.5687482025
GSE28863_A4Down-0.6039729911
GSE48662Down-0.0745198322

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Coagulation factor VIIa Recombinant HumanDB00036 BTD00006 | BIOD00006
2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINEDB07207 -
[2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREADB07247 -
{5-(5-AMINO-1H-PYRROLO[3,2-B]PYRIDIN-2-YL)-6-HYDROXY-3'-NITRO-BIPHENYL-3-YL]-ACETIC ACIDDB08232 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-375MIMAT0000728MIRT019927MicroarrayFunctional MTI (Weak)20215506
hsa-miR-130b-3pMIMAT0000691MIRT020315SequencingFunctional MTI (Weak)20371350
hsa-miR-124-3pMIMAT0000422MIRT022817MicroarrayFunctional MTI (Weak)18668037
hsa-miR-93-5pMIMAT0000093MIRT028146SequencingFunctional MTI (Weak)20371350
hsa-miR-26b-5pMIMAT0000083MIRT029798MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

18813915Here, we compare aqueous acetonitrile and methanol gradients containing either trifluoroacetic acid (TFA) or heptafluorobutyric acid (HFBA) as ion-pairing agents to separate such peptide pairs
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