HCSGD entry for F2

1. General information

Official gene symbolF2
Entrez ID2147
Gene full namecoagulation factor II (thrombin)
Other gene symbolsPT RPRGL2 THPH1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001934Positive regulation of protein phosphorylationIDAbiological_process
GO:0004252Serine-type endopeptidase activityIDA IEAmolecular_function
GO:0005102Receptor bindingIPImolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEA TAScellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005788Endoplasmic reticulum lumenTAScellular_component
GO:0005796Golgi lumenTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006508ProteolysisIEA TASbiological_process
GO:0006953Acute-phase responseIEAbiological_process
GO:0007166Cell surface receptor signaling pathwayIDAbiological_process
GO:0007275Multicellular organismal developmentTASbiological_process
GO:0007596Blood coagulationIEA TASbiological_process
GO:0007597Blood coagulation, intrinsic pathwayTASbiological_process
GO:0008083Growth factor activityTASmolecular_function
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0008360Regulation of cell shapeIEAbiological_process
GO:0009611Response to woundingIDAbiological_process
GO:0010468Regulation of gene expressionIEAbiological_process
GO:0010544Negative regulation of platelet activationTASbiological_process
GO:0014068Positive regulation of phosphatidylinositol 3-kinase signalingIEAbiological_process
GO:0017187Peptidyl-glutamic acid carboxylationTASbiological_process
GO:0030168Platelet activationIDA TASbiological_process
GO:0030193Regulation of blood coagulationTASbiological_process
GO:0030194Positive regulation of blood coagulationIDAbiological_process
GO:0030307Positive regulation of cell growthIEAbiological_process
GO:0032967Positive regulation of collagen biosynthetic processIDAbiological_process
GO:0042730FibrinolysisIDAbiological_process
GO:0043687Post-translational protein modificationTASbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0045861Negative regulation of proteolysisIDAbiological_process
GO:0048712Negative regulation of astrocyte differentiationIDAbiological_process
GO:0050900Leukocyte migrationTASbiological_process
GO:0051281Positive regulation of release of sequestered calcium ion into cytosolIDAbiological_process
GO:0051480Cytosolic calcium ion homeostasisIDAbiological_process
GO:0051918Negative regulation of fibrinolysisTASbiological_process
GO:0070053Thrombospondin receptor activityIDAmolecular_function
GO:1900738Positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathwayIDAbiological_process
GO:2000379Positive regulation of reactive oxygen species metabolic processIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.87667994000.35783313700.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1089915681
GSE13712_SHEARUp0.1781048885
GSE13712_STATICDown-0.1663995101
GSE19018Down-0.3166186434
GSE19899_A1Down-0.0940862261
GSE19899_A2Up0.2292325120
PubMed_21979375_A1Up0.0072976834
PubMed_21979375_A2Down-0.2638534655
GSE35957Down-0.0243892839
GSE36640Down-0.0078524936
GSE54402Down-0.0355015107
GSE9593Down-0.0232581509
GSE43922Up0.0233394672
GSE24585Up0.0262115290
GSE37065Down-0.0453607558
GSE28863_A1Down-0.1872180414
GSE28863_A2Down-0.2508275465
GSE28863_A3Up0.3195633414
GSE28863_A4Up0.1615481891
GSE48662Up0.0002673624

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT001360ProteomicsFunctional MTI (Weak)18668040
hsa-miR-16-5pMIMAT0000069MIRT001484pSILAC//Proteomics;OtherFunctional MTI (Weak)18668040
hsa-let-7b-5pMIMAT0000063MIRT001622ProteomicsFunctional MTI (Weak)18668040
hsa-miR-9-5pMIMAT0000441MIRT021414MicroarrayFunctional MTI (Weak)17612493
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.