HCSGD entry for EXT1

1. General information

Official gene symbolEXT1
Entrez ID2131
Gene full nameexostosin glycosyltransferase 1
Other gene symbolsEXT LGCR LGS TRPS2 TTV
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneTAScellular_component
GO:0001501Skeletal system developmentTASbiological_process
GO:0001503OssificationIMPbiological_process
GO:0005783Endoplasmic reticulumIDA IEAcellular_component
GO:0005789Endoplasmic reticulum membraneNAScellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005975Carbohydrate metabolic processTASbiological_process
GO:0006024Glycosaminoglycan biosynthetic processIDA TASbiological_process
GO:0006486Protein glycosylationIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007369GastrulationIEAbiological_process
GO:0007411Axon guidanceIEAbiological_process
GO:0007492Endoderm developmentIEAbiological_process
GO:0007498Mesoderm developmentIEAbiological_process
GO:0008375Acetylglucosaminyltransferase activityIDAmolecular_function
GO:0015012Heparan sulfate proteoglycan biosynthetic processIDA IEA ISSbiological_process
GO:0015014Heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic processIMPbiological_process
GO:0015020Glucuronosyltransferase activityIDAmolecular_function
GO:0016021Integral component of membraneTAScellular_component
GO:0016757Transferase activity, transferring glycosyl groupsIDAmolecular_function
GO:0021772Olfactory bulb developmentIEAbiological_process
GO:0030176Integral component of endoplasmic reticulum membraneISScellular_component
GO:0030203Glycosaminoglycan metabolic processTASbiological_process
GO:0033692Cellular polysaccharide biosynthetic processIDAbiological_process
GO:0042328Heparan sulfate N-acetylglucosaminyltransferase activityNASmolecular_function
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046982Protein heterodimerization activityIPImolecular_function
GO:0050508Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activityISS NASmolecular_function
GO:0050509N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activityISS NASmolecular_function
GO:0072498Embryonic skeletal joint developmentIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.55791712320.01639441890.99999024730.2497207755

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-1.5322038584
GSE13712_SHEARDown-0.3570436089
GSE13712_STATICUp0.0688313475
GSE19018Down-1.4485735435
GSE19899_A1Down-0.7094200899
GSE19899_A2Down-0.4807004640
PubMed_21979375_A1Down-0.8838872283
PubMed_21979375_A2Up0.3734568203
GSE35957Up0.7056209285
GSE36640Up0.3125204029
GSE54402Down-1.2213114287
GSE9593Down-0.0154281156
GSE43922Up0.0879424406
GSE24585Down-0.0810231199
GSE37065Down-0.0658761809
GSE28863_A1Up0.3748226097
GSE28863_A2Up0.5629341477
GSE28863_A3Up0.1313825164
GSE28863_A4Down-0.0991876999
GSE48662Down-0.1913421482

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-375MIMAT0000728MIRT020052MicroarrayFunctional MTI (Weak)20215506
hsa-miR-320aMIMAT0000510MIRT044632CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.