HCSGD entry for ALAS2

1. General information

Official gene symbolALAS2
Entrez ID212
Gene full nameaminolevulinate, delta-, synthase 2
Other gene symbolsALAS-E ALASE ANH1 ASB XLDPP XLEPP XLSA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001666Response to hypoxiaIDAbiological_process
GO:00038705-aminolevulinate synthase activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005739MitochondrionIDAcellular_component
GO:0005743Mitochondrial inner membraneIDAcellular_component
GO:0005759Mitochondrial matrixIEA TAScellular_component
GO:0006778Porphyrin-containing compound metabolic processIEA TASbiological_process
GO:0006782Protoporphyrinogen IX biosynthetic processIEAbiological_process
GO:0006783Heme biosynthetic processISS NAS TASbiological_process
GO:0006879Cellular iron ion homeostasisISSbiological_process
GO:0009058Biosynthetic processIEAbiological_process
GO:0016594Glycine bindingISSmolecular_function
GO:0030170Pyridoxal phosphate bindingIEAmolecular_function
GO:0030218Erythrocyte differentiationISS NASbiological_process
GO:0032364Oxygen homeostasisNASbiological_process
GO:0042541Hemoglobin biosynthetic processISSbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0050662Coenzyme bindingISSmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.83333350180.72227179440.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0460948043
GSE13712_SHEARUp0.1406055012
GSE13712_STATICDown-0.0763063205
GSE19018Down-0.0520414545
GSE19899_A1Down-0.0164984199
GSE19899_A2Up0.1098429935
PubMed_21979375_A1Up0.1126582779
PubMed_21979375_A2Down-0.0786163903
GSE35957Down-0.0369739422
GSE36640Down-0.0080746153
GSE54402Down-0.0289898974
GSE9593Down-0.0127895423
GSE43922Up0.0202049060
GSE24585Up0.3382490983
GSE37065Down-0.1971159833
GSE28863_A1Down-0.1130559316
GSE28863_A2Down-0.0641832874
GSE28863_A3Up0.0967799184
GSE28863_A4Up0.0460433647
GSE48662Up0.0339081638

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

GlycineDB00145 NUTR00028

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.