HCSGD entry for ETS2
1. General information
| Official gene symbol | ETS2 |
|---|---|
| Entrez ID | 2114 |
| Gene full name | v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) |
| Other gene symbols | ETS2IT1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IEA | molecular_function |
| GO:0001501 | Skeletal system development | TAS | biological_process |
| GO:0003677 | DNA binding | TAS | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0035259 | Glucocorticoid receptor binding | IEA | molecular_function |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0134085521 | 0.4787266517 | 0.2889914146 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0814635406 |
| GSE13712_SHEAR | Down | -0.5620943515 |
| GSE13712_STATIC | Down | -0.3031194353 |
| GSE19018 | Up | 0.4333201320 |
| GSE19899_A1 | Up | 0.5761778573 |
| GSE19899_A2 | Up | 0.5349485127 |
| PubMed_21979375_A1 | Up | 1.0229949904 |
| PubMed_21979375_A2 | Up | 1.4734792005 |
| GSE35957 | Down | -0.1752617257 |
| GSE36640 | Up | 0.3411528955 |
| GSE54402 | Up | 0.1398660065 |
| GSE9593 | Up | 0.0187933994 |
| GSE43922 | Up | 0.6471384444 |
| GSE24585 | Down | -0.5037976868 |
| GSE37065 | Up | 0.4030108149 |
| GSE28863_A1 | Up | 0.2725033436 |
| GSE28863_A2 | Up | 0.5964986606 |
| GSE28863_A3 | Down | -0.3992190044 |
| GSE28863_A4 | Up | 0.1221365628 |
| GSE48662 | Down | -0.3385181995 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-199a-3p | MIMAT0000232 | MIRT000775 | Microarray//Northern blot | Functional MTI (Weak) | 16331254 |
| hsa-miR-199a-5p | MIMAT0000231 | MIRT004398 | Microarray//Northern blot | Functional MTI (Weak) | 16331254 |
| hsa-miR-218-5p | MIMAT0000275 | MIRT024245 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-877-5p | MIMAT0004949 | MIRT037225 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045544 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-5p | MIMAT0000072 | MIRT050649 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 7 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25670864 | Structural insights into the autoregulation and cooperativity of the human transcription factor Ets-2 |
| 25670864 | Ets-2, like its closely related homologue Ets-1, is a member of the Ets family of DNA binding transcription factors |
| 25670864 | In contrast to Ets-1, in which the autoinhibition is caused by a combination of allosteric and steric mechanisms, we were unable to find clear evidence for the allosteric mechanism in Ets-2 |
| 21763315 | RuvBl2 cooperates with Ets2 to transcriptionally regulate hTERT in colon cancer |
| 21763315 | Using SILAC-proteomic analysis and molecular studies, we identified the AAA+ ATPase, RuvBl2 as a transcriptional regulator of hTERT and established that this regulation is through cooperation with Ets-2 |
| 19656618 | HBx induced DNA hypermethylation of p16(INK4a) promoter and subsequently interfered action of transcription factors like Ets1 and Ets2 activated by H(2)O(2) through the p38(MAPK) pathway, resulting in inhibition of its transcription |
| 19340300 | Of these, 56 are annotated as transcription factors, including two previously reported activators of the locus, ETS2 and JUNB |
| 17986575 | Ets2 may also play an important role in regulating the hTERT gene; but further studies are required to decipher the mechanisms in the regulation of telomerase activity |
| 15659210 | Senescence was accompanied by a decline in transcript levels of the polycomb gene Bmi-1, Ets1 and Ets2 transcription factors, and Id1, Id2 and Id3 helix-loop-helix proteins, suggesting roles for these genes in maintenance of cardiomyocyte proliferative capacity |
| 11234019 | Here we demonstrate a role for the Ets1 and Ets2 transcription factors based on their ability to activate the p16INK4a promoter through an ETS-binding site and their patterns of expression during the lifespan of human diploid fibroblasts |
| 11234019 | The induction of p16INK4a by Ets2, which is abundant in young human diploid fibroblasts, is potentiated by signalling through the Ras-Raf-MEK kinase cascade and inhibited by a direct interaction with the helix-loop-helix protein Id1 (ref |
| 11234019 | In senescent cells, where the Ets2 levels and MEK signalling decline, the marked increase in p16INK4a expression is consistent with the reciprocal reduction of Id1 and accumulation of Ets1 |
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