HCSGD entry for ALAS1
1. General information
| Official gene symbol | ALAS1 |
|---|---|
| Entrez ID | 211 |
| Gene full name | aminolevulinate, delta-, synthase 1 |
| Other gene symbols | ALAS ALAS3 ALASH MIG4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003824 | Catalytic activity | IEA | molecular_function |
| GO:0003870 | 5-aminolevulinate synthase activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0006778 | Porphyrin-containing compound metabolic process | TAS | biological_process |
| GO:0006782 | Protoporphyrinogen IX biosynthetic process | IEA | biological_process |
| GO:0006783 | Heme biosynthetic process | TAS | biological_process |
| GO:0009058 | Biosynthetic process | IEA | biological_process |
| GO:0030170 | Pyridoxal phosphate binding | IEA | molecular_function |
| GO:0044255 | Cellular lipid metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0013706660 | 0.9904360815 | 0.0996610497 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 1.3564696615 |
| GSE13712_SHEAR | Down | -0.0442207542 |
| GSE13712_STATIC | Up | 0.1268259603 |
| GSE19018 | Down | -0.3390636093 |
| GSE19899_A1 | Up | 1.9669450965 |
| GSE19899_A2 | Up | 1.4310136189 |
| PubMed_21979375_A1 | Up | 1.7740240657 |
| PubMed_21979375_A2 | Up | 1.7701137735 |
| GSE35957 | Down | -0.3141707872 |
| GSE36640 | Up | 1.3600091035 |
| GSE54402 | Up | 1.0391867382 |
| GSE9593 | Down | -0.0844765270 |
| GSE43922 | Up | 0.8616966895 |
| GSE24585 | Up | 0.1986625290 |
| GSE37065 | Up | 0.2329120194 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.0886905710 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Glycine | DB00145 | NUTR00028 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-484 | MIMAT0002174 | MIRT042198 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-3p | MIMAT0001340 | MIRT042490 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 16306232 | In contrast, the genes for the controlling enzymes of heme synthesis and degradation (5-aminolevulinate synthase 1 and heme oxygenase 1, respectively) were up-regulated, implying depletion of a regulatory heme pool |
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