HCSGD entry for ERCC3

1. General information

Official gene symbolERCC3
Entrez ID2071
Gene full nameexcision repair cross-complementing rodent repair deficiency, complementation group 3
Other gene symbolsBTF2 GTF2H RAD25 TFIIH XPB
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000441SSL2-core TFIIH complexIEAcellular_component
GO:0000717Nucleotide-excision repair, DNA duplex unwindingIMPbiological_process
GO:0000718Nucleotide-excision repair, DNA damage removalTASbiological_process
GO:0001666Response to hypoxiaIEAbiological_process
GO:0003677DNA bindingIEA TASmolecular_function
GO:0003684Damaged DNA bindingNASmolecular_function
GO:0004003ATP-dependent DNA helicase activityIEAmolecular_function
GO:0004672Protein kinase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005525GTP bindingIEAmolecular_function
GO:0005634NucleusTAScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005675Holo TFIIH complexIDA TAScellular_component
GO:0006265DNA topological changeIMPbiological_process
GO:0006281DNA repairIMP TASbiological_process
GO:0006283Transcription-coupled nucleotide-excision repairIDA TASbiological_process
GO:0006289Nucleotide-excision repairIEA IMP TASbiological_process
GO:0006360Transcription from RNA polymerase I promoterTASbiological_process
GO:0006361Transcription initiation from RNA polymerase I promoterTASbiological_process
GO:0006362Transcription elongation from RNA polymerase I promoterTASbiological_process
GO:0006363Termination of RNA polymerase I transcriptionTASbiological_process
GO:0006366Transcription from RNA polymerase II promoterIDA IMP TASbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0006368Transcription elongation from RNA polymerase II promoterTASbiological_process
GO:00063707-methylguanosine mRNA cappingTASbiological_process
GO:0006915Apoptotic processIMPbiological_process
GO:0006979Response to oxidative stressIMPbiological_process
GO:0008022Protein C-terminus bindingIPImolecular_function
GO:0008094DNA-dependent ATPase activityIDA IMPmolecular_function
GO:0008104Protein localizationIMPbiological_process
GO:0008134Transcription factor bindingIDAmolecular_function
GO:0008353RNA polymerase II carboxy-terminal domain kinase activityIDA IEAmolecular_function
GO:0009411Response to UVIMPbiological_process
GO:0009650UV protectionIEAbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016032Viral processTASbiological_process
GO:0016887ATPase activityIDAmolecular_function
GO:0032564DATP bindingIEAmolecular_function
GO:0033683Nucleotide-excision repair, DNA incisionIMPbiological_process
GO:0035315Hair cell differentiationIMPbiological_process
GO:0042277Peptide bindingIEAmolecular_function
GO:0043065Positive regulation of apoptotic processIDAbiological_process
GO:00431383'-5' DNA helicase activityIDA IMPmolecular_function
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0047485Protein N-terminus bindingIPImolecular_function
GO:0050434Positive regulation of viral transcriptionTASbiological_process
GO:1901990Regulation of mitotic cell cycle phase transitionIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.27310341930.45932087310.97020709371.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3717034951
GSE13712_SHEARDown-0.3495137158
GSE13712_STATICDown-0.1942455103
GSE19018Down-0.3013542970
GSE19899_A1Up0.1631577733
GSE19899_A2Up0.5306936450
PubMed_21979375_A1Up0.7882088428
PubMed_21979375_A2Up0.5866742857
GSE35957Down-0.0218034123
GSE36640Down-0.0732336608
GSE54402Up0.4528010595
GSE9593Up0.1015592953
GSE43922Down-0.0582034320
GSE24585Down-0.0299298049
GSE37065Up0.0210005643
GSE28863_A1Down-0.0161881435
GSE28863_A2Up0.3562085324
GSE28863_A3Down-0.5382807841
GSE28863_A4Down-0.2616487017
GSE48662Down-0.2514462591

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-192-5pMIMAT0000222MIRT004849Luciferase reporter assay//qRT-PCR//Reporter assay;Microarray;OtherFunctional MTI19074876
hsa-miR-192-5pMIMAT0000222MIRT004849Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI21672525
hsa-miR-215-5pMIMAT0000272MIRT024493MicroarrayFunctional MTI (Weak)19074876
hsa-miR-186-5pMIMAT0000456MIRT045169CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.