HCSGD entry for ERCC2

1. General information

Official gene symbolERCC2
Entrez ID2068
Gene full nameexcision repair cross-complementing rodent repair deficiency, complementation group 2
Other gene symbolsCOFS2 EM9 TTD XPD
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000441SSL2-core TFIIH complexIEAcellular_component
GO:0000718Nucleotide-excision repair, DNA damage removalTASbiological_process
GO:0001666Response to hypoxiaIEAbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0004003ATP-dependent DNA helicase activityIEAmolecular_function
GO:0004672Protein kinase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005675Holo TFIIH complexIDA TAScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005819SpindleIDAcellular_component
GO:0006200ATP catabolic processIDA TASbiological_process
GO:0006281DNA repairTASbiological_process
GO:0006283Transcription-coupled nucleotide-excision repairIDA TASbiological_process
GO:0006289Nucleotide-excision repairIEA IGI NAS TASbiological_process
GO:0006360Transcription from RNA polymerase I promoterTASbiological_process
GO:0006361Transcription initiation from RNA polymerase I promoterTASbiological_process
GO:0006362Transcription elongation from RNA polymerase I promoterTASbiological_process
GO:0006363Termination of RNA polymerase I transcriptionTASbiological_process
GO:0006366Transcription from RNA polymerase II promoterIDA TASbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0006368Transcription elongation from RNA polymerase II promoterTASbiological_process
GO:00063707-methylguanosine mRNA cappingTASbiological_process
GO:0006468Protein phosphorylationIDAbiological_process
GO:0006915Apoptotic processIMPbiological_process
GO:0006979Response to oxidative stressIEA IMPbiological_process
GO:0007059Chromosome segregationIMPbiological_process
GO:0007568AgingIEAbiological_process
GO:0008022Protein C-terminus bindingIPImolecular_function
GO:0008094DNA-dependent ATPase activityIDA TASmolecular_function
GO:0008283Cell proliferationIEAbiological_process
GO:0008353RNA polymerase II carboxy-terminal domain kinase activityIDAmolecular_function
GO:0009650UV protectionIEA IGIbiological_process
GO:0009791Post-embryonic developmentIEAbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016032Viral processTASbiological_process
GO:0016310PhosphorylationIDAbiological_process
GO:0019907Cyclin-dependent protein kinase activating kinase holoenzyme complexIDAcellular_component
GO:0021510Spinal cord developmentIEAbiological_process
GO:0030198Extracellular matrix organizationIEAbiological_process
GO:0030282Bone mineralizationIEAbiological_process
GO:0032289Central nervous system myelin formationIEAbiological_process
GO:0032508DNA duplex unwindingIDAbiological_process
GO:0033683Nucleotide-excision repair, DNA incisionIMPbiological_process
GO:0035264Multicellular organism growthIEAbiological_process
GO:0035315Hair cell differentiationIEA IMPbiological_process
GO:0040016Embryonic cleavageIEAbiological_process
GO:00431395'-3' DNA helicase activityIDAmolecular_function
GO:0043249Erythrocyte maturationIEAbiological_process
GO:0043388Positive regulation of DNA bindingIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0047485Protein N-terminus bindingIPImolecular_function
GO:0048820Hair follicle maturationIEAbiological_process
GO:0050434Positive regulation of viral transcriptionTASbiological_process
GO:00515394 iron, 4 sulfur cluster bindingIEAmolecular_function
GO:0060218Hematopoietic stem cell differentiationIEAbiological_process
GO:0071817MMXD complexIDAcellular_component
GO:1901990Regulation of mitotic cell cycle phase transitionIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.69981707380.11462135940.99999024730.6486035254

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1295357883
GSE13712_SHEARUp0.0979908118
GSE13712_STATICUp0.4950431258
GSE19018Down-0.1519666182
GSE19899_A1Down-0.2521033460
GSE19899_A2Up0.0142517578
PubMed_21979375_A1Up0.5748148689
PubMed_21979375_A2Up0.2663924081
GSE35957Up0.2806101021
GSE36640Up0.0489609609
GSE54402Down-0.0263059629
GSE9593Down-0.1206848466
GSE43922Down-0.3137136578
GSE24585Down-0.0970822190
GSE37065Down-0.7111669173
GSE28863_A1Down-0.3575689800
GSE28863_A2Down-0.2648984152
GSE28863_A3Down-0.1069250085
GSE28863_A4Down-0.0251559821
GSE48662Up0.1199931735

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1226-3pMIMAT0005577MIRT036466CLASHFunctional MTI (Weak)23622248
hsa-miR-17-5pMIMAT0000070MIRT050977CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22705887METHODS AND RESULTS: In mice with genomic instability resulting from the defective nucleotide excision repair genes ERCC1 and XPD (Ercc1(d/-) and Xpd(TTD) mice), we explored age-dependent vascular function compared with that in wild-type mice
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