HCSGD entry for ERBB4

1. General information

Official gene symbolERBB4
Entrez ID2066
Gene full namev-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
Other gene symbolsHER4 p180erbB4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001755Neural crest cell migrationIEA ISSbiological_process
GO:0001934Positive regulation of protein phosphorylationTASbiological_process
GO:0004713Protein tyrosine kinase activityIDAmolecular_function
GO:0004714Transmembrane receptor protein tyrosine kinase activityIDA IEAmolecular_function
GO:0004716Receptor signaling protein tyrosine kinase activityIEAmolecular_function
GO:0005154Epidermal growth factor receptor bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIDAcellular_component
GO:0005759Mitochondrial matrixTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0007165Signal transductionIDAbiological_process
GO:0007169Transmembrane receptor protein tyrosine kinase signaling pathwayIDA IEAbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007399Nervous system developmentISSbiological_process
GO:0007507Heart developmentIEA ISSbiological_process
GO:0007595LactationIEA IMPbiological_process
GO:0008283Cell proliferationTASbiological_process
GO:0008284Positive regulation of cell proliferationIMPbiological_process
GO:0008285Negative regulation of cell proliferationIMPbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0009880Embryonic pattern specificationIEA ISSbiological_process
GO:0016020MembraneIEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016323Basolateral plasma membraneIDAcellular_component
GO:0016477Cell migrationIDAbiological_process
GO:0018108Peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0021551Central nervous system morphogenesisIEA ISSbiological_process
GO:0021889Olfactory bulb interneuron differentiationIEA ISSbiological_process
GO:0030334Regulation of cell migrationIEA ISSbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0042523Positive regulation of tyrosine phosphorylation of Stat5 proteinIEA IMPbiological_process
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0043066Negative regulation of apoptotic processIMPbiological_process
GO:0043235Receptor complexIDAcellular_component
GO:0043552Positive regulation of phosphatidylinositol 3-kinase activityIDAbiological_process
GO:0043653Mitochondrial fragmentation involved in apoptotic processIMPbiological_process
GO:0044212Transcription regulatory region DNA bindingIMPmolecular_function
GO:0045087Innate immune responseTASbiological_process
GO:0045165Cell fate commitmentIEAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIEA IMPbiological_process
GO:0046777Protein autophosphorylationIDAbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingTASbiological_process
GO:0060045Positive regulation of cardiac muscle cell proliferationIEA ISSbiological_process
GO:0060644Mammary gland epithelial cell differentiationIEA ISSbiological_process
GO:0060749Mammary gland alveolus developmentIEA ISSbiological_process
GO:0061026Cardiac muscle tissue regenerationIEA ISSbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIMPbiological_process
GO:2000366Positive regulation of STAT protein import into nucleusIEA IMPbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.47468071500.94821951670.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0491910876
GSE13712_SHEARDown-0.0075847776
GSE13712_STATICDown-0.1722069340
GSE19018Up0.0782684803
GSE19899_A1Up0.1536015138
GSE19899_A2Up0.0799060813
PubMed_21979375_A1Up0.0992126202
PubMed_21979375_A2Up0.0095275735
GSE35957Up0.1420599355
GSE36640Up0.0864265108
GSE54402Up0.0272752855
GSE9593Up0.0402867464
GSE43922Up0.0139275162
GSE24585Up0.1827226338
GSE37065Down-0.0071437787
GSE28863_A1Down-0.0333853639
GSE28863_A2Up0.6296362016
GSE28863_A3Up0.0406136621
GSE28863_A4Up0.0153853866
GSE48662Up0.0239822194

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

AfatinibDB08916 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-372-3pMIMAT0000724MIRT003532Luciferase reporter assay//MicroarrayFunctional MTI19885849
hsa-miR-19a-3pMIMAT0000073MIRT003533Luciferase reporter assay//MicroarrayFunctional MTI19885849
hsa-miR-302d-3pMIMAT0000718MIRT003534Luciferase reporter assay//MicroarrayFunctional MTI19885849
hsa-miR-146a-5pMIMAT0000449MIRT005806Luciferase reporter assay//Microarray//Western blotFunctional MTI20864407
Entries Per Page
Displaying Page of
    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-302d-3pMIMAT0000718NAhsa-miR-302d19885849
hsa-miR-19a-3pMIMAT0000073NAhsa-miR-19a19885849
Entries Per Page
Displaying Page of

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26420857PURPOSE: Aberrant regulation of the EGF receptor family (EGFR, HER2, HER3, HER4) contributes to tumorigenesis and metastasis in epithelial cancers
Entries Per Page
Displaying Page of