HCSGD entry for ERBB3
1. General information
| Official gene symbol | ERBB3 |
|---|---|
| Entrez ID | 2065 |
| Gene full name | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) |
| Other gene symbols | ErbB-3 HER3 LCCS2 MDA-BF-1 c-erbB-3 c-erbB3 erbB3-S p180-ErbB3 p45-sErbB3 p85-sErbB3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003197 | Endocardial cushion development | IEA | biological_process |
| GO:0004672 | Protein kinase activity | IEA | molecular_function |
| GO:0004713 | Protein tyrosine kinase activity | IDA | molecular_function |
| GO:0004714 | Transmembrane receptor protein tyrosine kinase activity | IEA | molecular_function |
| GO:0004888 | Transmembrane signaling receptor activity | ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005615 | Extracellular space | IDA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0007162 | Negative regulation of cell adhesion | IDA | biological_process |
| GO:0007165 | Signal transduction | IDA | biological_process |
| GO:0007169 | Transmembrane receptor protein tyrosine kinase signaling pathway | IEA ISS | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007422 | Peripheral nervous system development | ISS | biological_process |
| GO:0007507 | Heart development | ISS | biological_process |
| GO:0008543 | Fibroblast growth factor receptor signaling pathway | TAS | biological_process |
| GO:0009968 | Negative regulation of signal transduction | IDA | biological_process |
| GO:0014037 | Schwann cell differentiation | IEA ISS | biological_process |
| GO:0014065 | Phosphatidylinositol 3-kinase signaling | IDA | biological_process |
| GO:0014068 | Positive regulation of phosphatidylinositol 3-kinase signaling | TAS | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0016323 | Basolateral plasma membrane | IDA | cellular_component |
| GO:0016324 | Apical plasma membrane | IEA | cellular_component |
| GO:0016328 | Lateral plasma membrane | IEA | cellular_component |
| GO:0019838 | Growth factor binding | IPI ISS | molecular_function |
| GO:0021545 | Cranial nerve development | IEA ISS | biological_process |
| GO:0030296 | Protein tyrosine kinase activator activity | IDA | molecular_function |
| GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | biological_process |
| GO:0042060 | Wound healing | NAS | biological_process |
| GO:0042127 | Regulation of cell proliferation | IDA | biological_process |
| GO:0042803 | Protein homodimerization activity | NAS | molecular_function |
| GO:0043235 | Receptor complex | IDA ISS | cellular_component |
| GO:0043524 | Negative regulation of neuron apoptotic process | IEA ISS | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0046982 | Protein heterodimerization activity | IDA IPI | molecular_function |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048015 | Phosphatidylinositol-mediated signaling | TAS | biological_process |
| GO:0051048 | Negative regulation of secretion | IDA | biological_process |
| GO:0051402 | Neuron apoptotic process | IMP | biological_process |
| GO:0061098 | Positive regulation of protein tyrosine kinase activity | IMP | biological_process |
| GO:0097192 | Extrinsic apoptotic signaling pathway in absence of ligand | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5609030698 | 0.8948549447 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0287262651 |
| GSE13712_SHEAR | Down | -0.1430639912 |
| GSE13712_STATIC | Down | -0.0333324490 |
| GSE19018 | Up | 0.1041521205 |
| GSE19899_A1 | Up | 0.0504570337 |
| GSE19899_A2 | Up | 0.0819360941 |
| PubMed_21979375_A1 | Down | -0.1303591558 |
| PubMed_21979375_A2 | Up | 0.1370405455 |
| GSE35957 | Up | 0.3724248342 |
| GSE36640 | Up | 0.0747116930 |
| GSE54402 | Down | -0.0767896212 |
| GSE9593 | Up | 0.1048128286 |
| GSE43922 | Up | 0.0601360698 |
| GSE24585 | Up | 0.3407782662 |
| GSE37065 | Down | -0.0451009112 |
| GSE28863_A1 | Down | -0.0411288307 |
| GSE28863_A2 | Down | -0.0525687864 |
| GSE28863_A3 | Up | 0.1933960051 |
| GSE28863_A4 | Up | 0.1008815920 |
| GSE48662 | Down | -0.1145549072 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-22-3p | MIMAT0000077 | MIRT006210 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 22484852 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT002938 | Luciferase reporter assay//Northern blot//qRT-PCR//Western blot | Functional MTI | 17110380 |
| hsa-miR-205-5p | MIMAT0000266 | MIRT003659 | Luciferase reporter assay//Reporter assay;Other | Functional MTI | 19238171 |
| hsa-miR-205-5p | MIMAT0000266 | MIRT003659 | Luciferase reporter assay | Functional MTI | 20065103 |
| hsa-miR-205-5p | MIMAT0000266 | MIRT003659 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 19276373 |
| hsa-miR-205-5p | MIMAT0000266 | MIRT003659 | Luciferase reporter assay//Microarray//Western blot | Functional MTI | 20864407 |
| hsa-miR-125a-5p | MIMAT0000443 | MIRT005117 | Luciferase reporter assay//Northern blot//qRT-PCR//Western blot | Functional MTI | 17110380 |
| hsa-miR-125a-5p | MIMAT0000443 | MIRT005117 | Luciferase reporter assay//Microarray//Western blot | Functional MTI | 20864407 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030589 | Microarray | Functional MTI (Weak) | 19748357 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-125a-5p | MIMAT0000443 | 1 | hsa-miR-125a-5p | {Western blot} | {overexpression by mature miRNA transfection} | 17110380 | |
| hsa-miR-125b-5p | MIMAT0000423 | 1 | hsa-miR-125b | {Western blot} | {overexpression by mature miRNA transfection} | 17110380 | |
| hsa-miR-205-5p | MIMAT0000266 | 1 | hsa-miR-205 | {Western blot} | {overexpression} | 19238171 | |
| hsa-miR-205-5p | MIMAT0000266 | 1 | hsa-miR-205 | {Western blot} | {overexpression by miRNA precursor transfection} | 19276373 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26420857 | PURPOSE: Aberrant regulation of the EGF receptor family (EGFR, HER2, HER3, HER4) contributes to tumorigenesis and metastasis in epithelial cancers |
| 26420857 | Pan-HER represents a novel molecular targeted therapeutic composed of a mixture of six monoclonal antibodies against EGFR, HER2, and HER3 |
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