HCSGD entry for EPO

1. General information

Official gene symbolEPO
Entrez ID2056
Gene full nameerythropoietin
Other gene symbolsEP MVCD2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005128Erythropoietin receptor bindingIEAmolecular_function
GO:0005179Hormone activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0006915Apoptotic processIEAbiological_process
GO:0007165Signal transductionNASbiological_process
GO:0007566Embryo implantationIEAbiological_process
GO:0007568AgingIEAbiological_process
GO:0008015Blood circulationNASbiological_process
GO:0008284Positive regulation of cell proliferationIDAbiological_process
GO:0009651Response to salt stressIEAbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0010523Negative regulation of calcium ion transport into cytosolIDAbiological_process
GO:0018105Peptidyl-serine phosphorylationIEAbiological_process
GO:0030295Protein kinase activator activityIEAmolecular_function
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0033189Response to vitamin AIEAbiological_process
GO:0033574Response to testosteroneIEAbiological_process
GO:0042523Positive regulation of tyrosine phosphorylation of Stat5 proteinIDAbiological_process
GO:0042541Hemoglobin biosynthetic processIEAbiological_process
GO:0043249Erythrocyte maturationIEAbiological_process
GO:0043627Response to estrogenIEAbiological_process
GO:0045666Positive regulation of neuron differentiationIEAbiological_process
GO:0045740Positive regulation of DNA replicationIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0046579Positive regulation of Ras protein signal transductionIDAbiological_process
GO:0048678Response to axon injuryIEAbiological_process
GO:0051602Response to electrical stimulusIEAbiological_process
GO:0055093Response to hyperoxiaIEAbiological_process
GO:0061418Regulation of transcription from RNA polymerase II promoter in response to hypoxiaTASbiological_process
GO:0070555Response to interleukin-1IEAbiological_process
GO:0071456Cellular response to hypoxiaTASbiological_process
GO:0071474Cellular hyperosmotic responseIDAbiological_process
GO:1902219Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stressIDAbiological_process
GO:1902251Negative regulation of erythrocyte apoptotic processIDAbiological_process
GO:2001258Negative regulation of cation channel activityIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.42804117620.90557629650.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0668141190
GSE13712_SHEARDown-0.1890092304
GSE13712_STATICUp0.0509073430
GSE19018Up0.1359787536
GSE19899_A1Down-0.0931834105
GSE19899_A2Up0.1634866546
PubMed_21979375_A1Up0.1896890342
PubMed_21979375_A2Up0.0106203264
GSE35957Up0.0443052503
GSE36640Up0.1309402046
GSE54402Up0.0633205662
GSE9593Down-0.0645939563
GSE43922Up0.1647119205
GSE24585Up0.0512264200
GSE37065Down-0.0838864179
GSE28863_A1Down-0.1090150241
GSE28863_A2Up0.2066355622
GSE28863_A3Up0.4206029539
GSE28863_A4Up0.0403805914
GSE48662Up0.0948877258

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 10 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26610640Erythropoietin preconditioning improves clinical and histologic outcome in an acute spinal cord ischemia and reperfusion rabbit model
26610640OBJECTIVE: This study examined effects and functional outcome of recombinant human erythropoietin (rhEPO) and carbamylated erythropoietin fusion protein (cEPO-FC) preconditioning in a rabbit model for spinal cord ischemia and resulting paraplegia
24592241Neocytolysis is the hypothesis formulated to explain experimental evidence of selective lysis of young red blood cells (RBCs) (neocytes) associated with decreased plasma levels of erythropoietin (EPO)
24592241Neocytolysis is the hypothesis formulated to explain experimental evidence of selective lysis of young red blood cells (RBCs) (neocytes) associated with decreased plasma levels of erythropoietin (EPO)
24592241EPO plasma levels then decline and a decrease in RBC mass takes place, apparently because of the selective lysis of the youngest, recently generated RBCs (neocytes)
24592241After descent, the polycythaemia developed at high altitude must be abrogated, and a rapid reduction in the number of circulating RBCs is obtained by a decrease in EPO synthesis and the lysis of what seem to be young RBCs
24592241In vivo, neocytolysis seems to be abolished by EPO administration
24592241Why neocytes are specifically destroyed and how is this related to decreased EPO levels has not yet been elucidated
19782086Erythropoietin (EPO) prevents cell apoptosis induced by oxidative stress
19782086Carbamylated EPO maintains the tissue-protective activities of the unmodified EPO but does not stimulate erythropoiesis
19782086Carbamylated EPO maintains the tissue-protective activities of the unmodified EPO but does not stimulate erythropoiesis
19782086This study evaluates whether carbamylated erythropoietin is as effective as recombinant human erythropoietin in protecting endothelial progenitor cells (EPCs) from apoptosis without stimulating erythropoiesis
19782086In UT-7, carbamylated erythropoietin (C-darbe) induced phosphorylation of the anti-apoptotic Jak-2/Akt signal and, as opposed to recombinant human erythropoietin (darbe), did not produce a significant activation of cell proliferating signals
18924487Produced in low/moderate concentrations as molecular signals that regulate a series of physiological processes, such as a defence against infectious agents, the maintenance of vascular tone, the control of ventilation and erythropoietin production, and signal transduction from membrane receptors in various physiological processes
18466174The serum erythropoietin (sEPO) and hemoglobin (Hb) levels in peripheral blood were also determined
17402563Finally, we found that erythropoietin is an ischemia-induced angiogenic factor that acts independently and as potently as VEGF in proliferative diabetic retinopathy (PDR)
17188915A selective lysis of relatively young erythrocytes (neocytolysis), together with a decrease of erythropoietin (EPO) production, has been described in polycythemic, high altitude acclimatized climbers, after descent to sea level, and in astronauts, soon after exposure to weightlessness (Alfrey CP, Rice L, Udden MM, Driscoll TB
17188915A selective lysis of relatively young erythrocytes (neocytolysis), together with a decrease of erythropoietin (EPO) production, has been described in polycythemic, high altitude acclimatized climbers, after descent to sea level, and in astronauts, soon after exposure to weightlessness (Alfrey CP, Rice L, Udden MM, Driscoll TB
16827160In the immortalized HDFs, the transcriptional activity of HIF-1alpha was also evident by the accumulation of its main downstream gene targets, namely erythropoietin (EPO) and the vascular endothelial growth factor (VEGF)
16827160In the immortalized HDFs, the transcriptional activity of HIF-1alpha was also evident by the accumulation of its main downstream gene targets, namely erythropoietin (EPO) and the vascular endothelial growth factor (VEGF)
10869423In situ RNA hybridization revealed that renox is highly expressed at the site of erythropoietin production in the renal cortex, showing the greatest accumulation of renox mRNA in proximal convoluted tubule epithelial cells
10027758Maze learning impairment is associated with stress hemopoiesis induced by chronic treatment of aged rats with human recombinant erythropoietin
10027758We evaluated hematological changes in 21-mo old male Fischer 344 rats undergoing a 3-mo twice weekly subcutaneous injection of human recombinant erythropoietin (EPO)
10027758We evaluated hematological changes in 21-mo old male Fischer 344 rats undergoing a 3-mo twice weekly subcutaneous injection of human recombinant erythropoietin (EPO)
10027758A baseline hematocrit (HCT) was obtained initially and repeated at monthly intervals to determine the effectiveness of EPO treatment
10027758At 24-mo of age and after 3 mo EPO treatment, the rats were tested for their ability to learn a 14-unit T maze
10027758After 1 mo EPO treatment, HCT significantly increased compared to saline-injected controls
10027758After 3 mo EPO treatment, MCV was significantly lower in EPO-treated rats compared to controls
10027758The G, which measures the membrane contribution to deformability, very significantly increased with EPO treatment
10027758This finding indicates an increased contribution of membrane properties to the MCTT after EPO treatment, which cancels the expected decrease in MCTT for smaller cells
10027758After 3 mo of EPO treatment, aged rats exhibited significantly impaired maze learning compared to controls
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