HCSGD entry for EPHB2

1. General information

Official gene symbolEPHB2
Entrez ID2048
Gene full nameEPH receptor B2
Other gene symbolsCAPB DRT EK5 EPHT3 ERK Hek5 PCBC Tyro5
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001525AngiogenesisISSbiological_process
GO:0001655Urogenital system developmentISSbiological_process
GO:0004713Protein tyrosine kinase activityISSmolecular_function
GO:0005003Ephrin receptor activityIEAmolecular_function
GO:0005005Transmembrane-ephrin receptor activityISS TASmolecular_function
GO:0005102Receptor bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005887Integral component of plasma membraneIEA ISScellular_component
GO:0007399Nervous system developmentTASbiological_process
GO:0007411Axon guidanceISS TASbiological_process
GO:0007413Axonal fasciculationISSbiological_process
GO:0007612LearningIEAbiological_process
GO:0008046Axon guidance receptor activityIEAmolecular_function
GO:0016021Integral component of membraneIEAcellular_component
GO:0016310PhosphorylationISSbiological_process
GO:0018108Peptidyl-tyrosine phosphorylationISSbiological_process
GO:0021631Optic nerve morphogenesisIEAbiological_process
GO:0021952Central nervous system projection neuron axonogenesisIEAbiological_process
GO:0022038Corpus callosum developmentISSbiological_process
GO:0030424AxonISScellular_component
GO:0030425DendriteISScellular_component
GO:0031290Retinal ganglion cell axon guidanceIEAbiological_process
GO:0042472Inner ear morphogenesisISSbiological_process
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0048013Ephrin receptor signaling pathwayISSbiological_process
GO:0048170Positive regulation of long-term neuronal synaptic plasticityIEAbiological_process
GO:0048593Camera-type eye morphogenesisIEAbiological_process
GO:0050771Negative regulation of axonogenesisIEAbiological_process
GO:0050878Regulation of body fluid levelsISSbiological_process
GO:0051965Positive regulation of synapse assemblyISSbiological_process
GO:0060021Palate developmentISSbiological_process
GO:0060996Dendritic spine developmentISSbiological_process
GO:0060997Dendritic spine morphogenesisISSbiological_process
GO:0071679Commissural neuron axon guidanceISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.30123611940.14465568940.99969783480.7324205424

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1790379378
GSE13712_SHEARDown-0.1196324969
GSE13712_STATICUp0.1320855809
GSE19018Down-0.8330861503
GSE19899_A1Down-0.0766071712
GSE19899_A2Down-0.3942745558
PubMed_21979375_A1Down-1.1264649096
PubMed_21979375_A2Down-0.0409015811
GSE35957Down-0.8011129204
GSE36640Up1.4913959328
GSE54402Up1.0293162687
GSE9593Down-0.1457532588
GSE43922Down-0.1459601432
GSE24585Down-0.2969150256
GSE37065Up0.1646489795
GSE28863_A1Up0.0478918792
GSE28863_A2Up0.0964635003
GSE28863_A3Up0.0926225800
GSE28863_A4Up0.0480739278
GSE48662Up0.1866787745

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Phosphoaminophosphonic Acid-Adenylate EsterDB04395 EXPT00524

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-92a-3pMIMAT0000092MIRT049727CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.