HCSGD entry for EPHA7

1. General information

Official gene symbolEPHA7
Entrez ID2045
Gene full nameEPH receptor A7
Other gene symbolsEHK3 HEK11
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004713Protein tyrosine kinase activityISSmolecular_function
GO:0005004GPI-linked ephrin receptor activityISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005887Integral component of plasma membraneIEAcellular_component
GO:0007420Brain developmentISSbiological_process
GO:0008046Axon guidance receptor activityISSmolecular_function
GO:0016310PhosphorylationISSbiological_process
GO:0018108Peptidyl-tyrosine phosphorylationISSbiological_process
GO:0022407Regulation of cell-cell adhesionISSbiological_process
GO:0030425DendriteIEAcellular_component
GO:0031290Retinal ganglion cell axon guidanceIEAbiological_process
GO:0031594Neuromuscular junctionIEAcellular_component
GO:0031952Regulation of protein autophosphorylationISSbiological_process
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043281Regulation of cysteine-type endopeptidase activity involved in apoptotic processISSbiological_process
GO:0043525Positive regulation of neuron apoptotic processISSbiological_process
GO:0045211Postsynaptic membraneIEAcellular_component
GO:0045499Chemorepellent activityISSmolecular_function
GO:0046875Ephrin receptor bindingIEAmolecular_function
GO:0048013Ephrin receptor signaling pathwayIDAbiological_process
GO:0048755Branching morphogenesis of a nerveISSbiological_process
GO:0050730Regulation of peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0050919Negative chemotaxisISSbiological_process
GO:0070372Regulation of ERK1 and ERK2 cascadeIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.48176834090.64913725540.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0575900908
GSE13712_SHEARUp0.0091491171
GSE13712_STATICDown-0.1352476626
GSE19018Up0.0017151783
GSE19899_A1Up0.0194470031
GSE19899_A2Up0.0608399029
PubMed_21979375_A1Up0.7052651460
PubMed_21979375_A2Up0.0420707910
GSE35957Down-0.0442455436
GSE36640Up0.0471357763
GSE54402Up0.6695625694
GSE9593Down-0.0416512332
GSE43922Up0.0137500677
GSE24585Down-0.4648991211
GSE37065Up0.2853287258
GSE28863_A1Down-0.1701535409
GSE28863_A2Up0.0821779841
GSE28863_A3Up0.1608312680
GSE28863_A4Up0.0082816946
GSE48662Down-0.0113281515

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

5-[(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamoyl}phenyl)amino]pyridine-3-carboxamideDB07970 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-196a-5pMIMAT0000226MIRT026092SequencingFunctional MTI (Weak)20371350
hsa-miR-93-5pMIMAT0000093MIRT028172SequencingFunctional MTI (Weak)20371350
hsa-miR-455-3pMIMAT0004784MIRT037905CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT039849CLASHFunctional MTI (Weak)23622248
hsa-miR-331-3pMIMAT0000760MIRT043415CLASHFunctional MTI (Weak)23622248
hsa-miR-125b-5pMIMAT0000423MIRT045990CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049149CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-758-3pMIMAT0003879NAhsa-miR-75821885853
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.