HCSGD entry for AK2
1. General information
| Official gene symbol | AK2 |
|---|---|
| Entrez ID | 204 |
| Gene full name | adenylate kinase 2 |
| Other gene symbols | ADK2 AK 2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001889 | Liver development | IEA | biological_process |
| GO:0004017 | Adenylate kinase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005743 | Mitochondrial inner membrane | IEA | cellular_component |
| GO:0005758 | Mitochondrial intermembrane space | IEA TAS | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0006119 | Oxidative phosphorylation | IEA | biological_process |
| GO:0006139 | Nucleobase-containing compound metabolic process | IEA | biological_process |
| GO:0006172 | ADP biosynthetic process | IEA | biological_process |
| GO:0007420 | Brain development | IEA | biological_process |
| GO:0015949 | Nucleobase-containing small molecule interconversion | TAS | biological_process |
| GO:0019205 | Nucleobase-containing compound kinase activity | IEA | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046033 | AMP metabolic process | IEA | biological_process |
| GO:0046034 | ATP metabolic process | IEA | biological_process |
| GO:0046060 | DATP metabolic process | IEA | biological_process |
| GO:0046939 | Nucleotide phosphorylation | TAS | biological_process |
| GO:0055086 | Nucleobase-containing small molecule metabolic process | TAS | biological_process |
| GO:0097066 | Response to thyroid hormone | IEA | biological_process |
| GO:0097226 | Sperm mitochondrial sheath | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9286135975 | 0.0604287755 | 0.9999902473 | 0.4629984021 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.6614477957 |
| GSE13712_SHEAR | Down | -0.0369911500 |
| GSE13712_STATIC | Up | 0.0099845376 |
| GSE19018 | Up | 0.2493829457 |
| GSE19899_A1 | Down | -0.0749623719 |
| GSE19899_A2 | Down | -0.1078479191 |
| PubMed_21979375_A1 | Down | -0.0189338662 |
| PubMed_21979375_A2 | Up | 0.0410038185 |
| GSE35957 | Down | -0.3281243926 |
| GSE36640 | Down | -0.4379128506 |
| GSE54402 | Up | 0.0626361865 |
| GSE9593 | Down | -0.1084141076 |
| GSE43922 | Down | -0.0808876064 |
| GSE24585 | Down | -0.3421592280 |
| GSE37065 | Up | 0.0457628869 |
| GSE28863_A1 | Down | -0.0177072380 |
| GSE28863_A2 | Up | 0.5292430184 |
| GSE28863_A3 | Down | -0.6949680190 |
| GSE28863_A4 | Down | -0.1144556979 |
| GSE48662 | Down | -0.2378766827 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Bis(Adenosine)-5'-Pentaphosphate | DB01717 | EXPT00535 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT002707 | Microarray//Microarray;Other | Functional MTI (Weak) | 15685193 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027808 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028621 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT032010 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-320a | MIMAT0000510 | MIRT044754 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193a-3p | MIMAT0000459 | MIRT044881 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049390 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
