HCSGD entry for ENDOG
1. General information
| Official gene symbol | ENDOG |
|---|---|
| Entrez ID | 2021 |
| Gene full name | endonuclease G |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001701 | In utero embryonic development | IEA | biological_process |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0004519 | Endonuclease activity | IEA | molecular_function |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0006309 | Apoptotic DNA fragmentation | IEA | biological_process |
| GO:0006310 | DNA recombination | TAS | biological_process |
| GO:0034612 | Response to tumor necrosis factor | IEA | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | IEA | biological_process |
| GO:0046677 | Response to antibiotic | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0631887238 | 0.6380149804 | 0.5429963867 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4150703835 |
| GSE13712_SHEAR | Up | 0.0636609926 |
| GSE13712_STATIC | Up | 0.4582976566 |
| GSE19018 | Up | 0.1494445149 |
| GSE19899_A1 | Up | 0.0927737078 |
| GSE19899_A2 | Up | 1.7597631609 |
| PubMed_21979375_A1 | Up | 1.8982759853 |
| PubMed_21979375_A2 | Up | 1.0011869652 |
| GSE35957 | Down | -0.6544354360 |
| GSE36640 | Up | 0.2920225283 |
| GSE54402 | Up | 0.4452733061 |
| GSE9593 | Down | -0.3795386807 |
| GSE43922 | Up | 0.0659735671 |
| GSE24585 | Up | 0.1131389240 |
| GSE37065 | Down | -0.1521788228 |
| GSE28863_A1 | Down | -0.1432832695 |
| GSE28863_A2 | Down | -0.0950509047 |
| GSE28863_A3 | Down | -0.2956358890 |
| GSE28863_A4 | Up | 0.0603653124 |
| GSE48662 | Down | -0.0061156751 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029630 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20211237 | Role of endonuclease G in senescence-associated cell death of human endothelial cells |
| 20211237 | In this communication, we addressed the role of endonuclease G (EndoG), a mitochondrial mediator of caspase-independent cell death, in senescence-associated cell death of human endothelial cells |
| 20211237 | Using immunofluorescence microscopy, we found, that EndoG is localized in the mitochondria in young cells, but relocalizes to the nucleus upon senescence |
| 20211237 | When EndoG gene expression was downregulated by lentiviral shRNA vectors, we found a significant reduction in the replicative life span and a corresponding increase in cell death |
| 20211237 | Together these observations suggest an important role of EndoG in the senescence program of human endothelial cells |
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