HCSGD entry for EN2
1. General information
| Official gene symbol | EN2 |
|---|---|
| Entrez ID | 2020 |
| Gene full name | engrailed homeobox 2 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0007275 | Multicellular organismal development | TAS | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0030901 | Midbrain development | IEA | biological_process |
| GO:0030902 | Hindbrain development | IEA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0048666 | Neuron development | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1855152122 | 0.8460686638 | 0.8418291946 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0403303777 |
| GSE13712_SHEAR | Up | 0.1803642965 |
| GSE13712_STATIC | Up | 0.0138538741 |
| GSE19018 | Up | 0.3195410985 |
| GSE19899_A1 | Up | 0.1365645050 |
| GSE19899_A2 | Up | 0.1642692338 |
| PubMed_21979375_A1 | Up | 0.1111167449 |
| PubMed_21979375_A2 | Up | 0.2222253342 |
| GSE35957 | Up | 0.1218337156 |
| GSE36640 | Up | 0.0459477455 |
| GSE54402 | Up | 0.0665309587 |
| GSE9593 | Down | -0.0446014808 |
| GSE43922 | Up | 0.1843132111 |
| GSE24585 | Down | -0.4767245400 |
| GSE37065 | Down | -0.1646173984 |
| GSE28863_A1 | Down | -0.1155554143 |
| GSE28863_A2 | Up | 0.1075218581 |
| GSE28863_A3 | Up | 0.2852905405 |
| GSE28863_A4 | Up | 0.0468784459 |
| GSE48662 | Up | 0.5794981694 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| N-Cyclohexyltaurine | DB03309 | EXPT02344 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027200 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT032001 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037416 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043555 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051493 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
