HCSGD entry for PIKFYVE

1. General information

Official gene symbolPIKFYVE
Entrez ID200576
Gene full namephosphoinositide kinase, FYVE finger containing
Other gene symbolsCFD FAB1 PIP5K PIP5K3 ZFYVE29
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneTAScellular_component
GO:00002851-phosphatidylinositol-3-phosphate 5-kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005829CytosolIEAcellular_component
GO:0006644Phospholipid metabolic processTASbiological_process
GO:0006661Phosphatidylinositol biosynthetic processTASbiological_process
GO:0006898Receptor-mediated endocytosisIMPbiological_process
GO:0010008Endosome membraneIDAcellular_component
GO:00163081-phosphatidylinositol-4-phosphate 5-kinase activityTASmolecular_function
GO:0016311DephosphorylationTASbiological_process
GO:0031410Cytoplasmic vesicleIEAcellular_component
GO:0031901Early endosome membraneIDA TAScellular_component
GO:0031902Late endosome membraneTAScellular_component
GO:0032288Myelin assemblyIEAbiological_process
GO:0034504Protein localization to nucleusIMPbiological_process
GO:0035556Intracellular signal transductionIEAbiological_process
GO:0036092Phosphatidylinositol-3-phosphate biosynthetic processTASbiological_process
GO:0042147Retrograde transport, endosome to GolgiIMPbiological_process
GO:0043813Phosphatidylinositol-3,5-bisphosphate 5-phosphatase activityTASmolecular_function
GO:0044267Cellular protein metabolic processIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045121Membrane raftIDAcellular_component
GO:0046854Phosphatidylinositol phosphorylationTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.34904964100.84368397860.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0266807293
GSE13712_SHEARDown-0.1328525405
GSE13712_STATICDown-0.1466397373
GSE19018Up0.0455691626
GSE19899_A1Up0.0722554513
GSE19899_A2Down-0.0331527002
PubMed_21979375_A1Up0.2435305009
PubMed_21979375_A2Up0.0776307675
GSE35957Up0.0584344106
GSE36640Down-0.0785861142
GSE54402Up0.4635859737
GSE9593Down-0.0001393286
GSE43922Up0.0133950210
GSE24585Up0.4134019103
GSE37065Up0.1305279562
GSE28863_A1Up0.3222721329
GSE28863_A2Up0.4077015059
GSE28863_A3Down-0.2875070230
GSE28863_A4Down-0.1870096765
GSE48662Down-0.0975173448

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-744-5pMIMAT0004945MIRT037422CLASHFunctional MTI (Weak)23622248
hsa-miR-324-3pMIMAT0000762MIRT042812CLASHFunctional MTI (Weak)23622248
hsa-miR-328-3pMIMAT0000752MIRT043808CLASHFunctional MTI (Weak)23622248
hsa-miR-100-5pMIMAT0000098MIRT048546CLASHFunctional MTI (Weak)23622248
hsa-miR-26a-5pMIMAT0000082MIRT050096CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.