HCSGD entry for A2M

1. General information

Official gene symbolA2M
Entrez ID2
Gene full namealpha-2-macroglobulin
Other gene symbolsA2MD CPAMD5 FWP007 S863-7
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001869Negative regulation of complement activation, lectin pathwayIDAbiological_process
GO:0002020Protease bindingIPImolecular_function
GO:0002576Platelet degranulationTASbiological_process
GO:0004866Endopeptidase inhibitor activityIEAmolecular_function
GO:0004867Serine-type endopeptidase inhibitor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionNAS TAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0007264Small GTPase mediated signal transductionTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0007597Blood coagulation, intrinsic pathwayTASbiological_process
GO:0010951Negative regulation of endopeptidase activityIDAbiological_process
GO:0019838Growth factor bindingIDAmolecular_function
GO:0019899Enzyme bindingIPImolecular_function
GO:0019959Interleukin-8 bindingIPImolecular_function
GO:0019966Interleukin-1 bindingIDAmolecular_function
GO:0030168Platelet activationTASbiological_process
GO:0031093Platelet alpha granule lumenTAScellular_component
GO:0043120Tumor necrosis factor bindingIDAmolecular_function
GO:0048863Stem cell differentiationIEAbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionTASbiological_process
GO:0052548Regulation of endopeptidase activityIDAbiological_process
GO:0070062Extracellular vesicular exosomeIDAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.87132348690.05347239850.99999024730.4358770517

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0712343765
GSE13712_SHEARDown-0.1126421028
GSE13712_STATICDown-0.1391315569
GSE19018Up0.7964290821
GSE19899_A1Down-1.1133019659
GSE19899_A2Up0.2398048796
PubMed_21979375_A1Down-0.0083488540
PubMed_21979375_A2Up0.0262450831
GSE35957Down-0.1520561246
GSE36640Down-0.6111369782
GSE54402Down-1.0442674117
GSE9593Down-0.2918838823
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.1728765052

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

BecaplerminDB00102 BTD00053 | BIOD00053
BacitracinDB00626 APRD00816
OcriplasminDB08888 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-128-3pMIMAT0000424MIRT021948MicroarrayFunctional MTI (Weak)17612493
hsa-miR-122-5pMIMAT0000421MIRT023224MicroarrayFunctional MTI (Weak)17612493
hsa-miR-98-5pMIMAT0000096MIRT027430MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24807532Fucoidan treatment also downregulated the expression of alpha(2)M
21541797Characterization of a novel positive transcription regulatory element that differentially regulates the alpha-2-macroglobulin gene in replicative senescence
21541797Alpha-2-macroglobulin (alpha2M), a protease inhibitor, is implicated in Alzheimer's disease, atherosclerosis, and other age-related diseases
21541797The elevated level of alpha2M mRNA has been described in replicative senescence and it could be used as a biomarker of the aging cells
21541797This report identified a novel transcriptional regulatory element, the alpha2M transcription enhancement element (ATEE), within the alpha2M promoter
21541797This element differentially activates alpha2M expression in senescent versus young fibroblasts
21541797Mutation within ATEE selectively abolished alpha2M promoter activity in senescent (but not young) cells
21541797These results indicated the ATEE, as a positive transcription regulatory element, contributes to the up-regulation of alpha2M during replicative senescence
15036401Among the differentially expressed genes, alpha-2-macroglobulin (alpha(2)M) was selected for further study
15036401Additional assays revealed that the levels of alpha(2)M increased in irreversible growth arrest induced by sublethal H(2)O(2), but not in quiescent state of cultured fibroblasts induced by serum-deprivation, and remained stable in Hela cells
15036401These results suggest that mRNA level of alpha(2)M can be used as a biomarker of aging in cultured fibroblasts
11250120Two-dimensional gel electrophoretic studies on the cellular aging: accumulation of alpha-2-macroglobulin in human fibroblasts with aging
11250120We found that the amount of an alpha-2-macroglobulin (A2M) fragment derived from culture medium increased in the cells with aging
11250120A2M is linked to Alzheimer's disease both genetically and functionally
11250120This is the first report of accumulation of an A2M fragment in senescent fibroblasts
112501202D gel analysis revealed that the A2M fragment was down-regulated in the immortalized cells, compared with their normal counterparts, regardless of their passage
11250120Our results suggest: (1) the A2M incorporation into the cells is increased in the process of cellular aging; and (2) A2M may be linked to the age-related phenotypes that were lost during the process of immortalization of human cells
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