HCSGD entry for ELAVL3

1. General information

Official gene symbolELAVL3
Entrez ID1995
Gene full nameELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)
Other gene symbolsHUC HUCL PLE21
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000166Nucleotide bindingIEAmolecular_function
GO:0003676Nucleic acid bindingIEAmolecular_function
GO:0007399Nervous system developmentIEAbiological_process
GO:0017091AU-rich element bindingIDAmolecular_function
GO:0030154Cell differentiationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.81614147260.71535765740.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0670959359
GSE13712_SHEARUp0.0055281373
GSE13712_STATICDown-0.0905954601
GSE19018Up0.0117352881
GSE19899_A1Up0.1005065997
GSE19899_A2Up0.1389361806
PubMed_21979375_A1Down-0.0015359415
PubMed_21979375_A2Down-0.2283551684
GSE35957Up0.0763211161
GSE36640Down-0.0964382308
GSE54402Up0.0001513503
GSE9593Up0.0784474293
GSE43922Up0.0542795072
GSE24585Down-0.0005405099
GSE37065Down-0.0416002416
GSE28863_A1Down-0.1368250592
GSE28863_A2Down-0.1298214918
GSE28863_A3Up0.4147488408
GSE28863_A4Up0.0431891889
GSE48662Down-0.0509725836

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT028772MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

11781834As a model, we utilized normal human prostate epithelial cell (HPEC) and human uroepithelial cell (HUC) cultures
9436977Elevation of p16, the CDKN2/p16 tumor suppressor gene (TSG) product, occurs at senescence in normal human uroepithelial cells (HUC)
9053853Using karyotypic and comparative genomic hybridization (CGH) analyses, chromosome losses and gains were analysed in six newly immortalized human uroepithelial cell (HUC) lines transformed by Human Papillomavirus 16 (HPV16) E7
7958891Parameters of genome instability and morphological alterations associated with cell transformation were studied in an isogeneic set of clonal human uroepithelial cell (HUC) lines immortalized by the human papilloma virus 16 (HPV16) E6 and/or E7 gene(s)
7958891We report that two independent E7-immortalized HUC lines showed minimal phenotypic or genotypic alterations, except that both lines contained amplification of 20q DNA sequences and a greater polyploidization at an early passage
7958891The E7-immortalized HUC line resembled normal HUC lines, except that they failed to senesce
7958891In contrast, the E6-immortalized HUC lines were morphologically altered, contained numerous random chromosome aberrations, and showed unstable evolving karyotypes with passage in culture
7958891No amplified DNA sequences were detected in E6-immortalized HUC lines
7958891E6-immortalized HUC lines showed transformed phenotypes similar to E6/E7-HUC lines
7958891The difference in genome stability between E6- and E7-immortalized HUC was highly significant statistically (p-value < 10(-6)
7958891Thus, the HPV16 E7 gene led to HUC immortalization by a pathway that blocked cellular senescence, but did not disrupt genome stability
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