HCSGD entry for AIF1

1. General information

Official gene symbolAIF1
Entrez ID199
Gene full nameallograft inflammatory factor 1
Other gene symbolsAIF-1 IBA1 IRT-1 IRT1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001774Microglial cell activationNASbiological_process
GO:0001891Phagocytic cupISScellular_component
GO:0003674Molecular_functionNDmolecular_function
GO:0005509Calcium ion bindingIEA ISSmolecular_function
GO:0005634NucleusIDA ISScellular_component
GO:0005737CytoplasmISScellular_component
GO:0005829CytosolIDAcellular_component
GO:0005884Actin filamentIDAcellular_component
GO:0006911Phagocytosis, engulfmentISSbiological_process
GO:0006954Inflammatory responseIEA ISS NASbiological_process
GO:0016601Rac protein signal transductionISSbiological_process
GO:0030027LamellipodiumISScellular_component
GO:0030041Actin filament polymerizationIDAbiological_process
GO:0032587Ruffle membraneIDAcellular_component
GO:0042102Positive regulation of T cell proliferationIDAbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0048661Positive regulation of smooth muscle cell proliferationIDAbiological_process
GO:0048662Negative regulation of smooth muscle cell proliferationIDAbiological_process
GO:0051015Actin filament bindingIDA IEAmolecular_function
GO:0051017Actin filament bundle assemblyIDAbiological_process
GO:0071346Cellular response to interferon-gammaIEP ISSbiological_process
GO:0071672Negative regulation of smooth muscle cell chemotaxisIDAbiological_process
GO:0071673Positive regulation of smooth muscle cell chemotaxisIDAbiological_process
GO:0090026Positive regulation of monocyte chemotaxisIDAbiological_process
GO:0097178Ruffle assemblyIEA ISS NASbiological_process
GO:1900087Positive regulation of G1/S transition of mitotic cell cycleIDAbiological_process
GO:2000406Positive regulation of T cell migrationIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.65974814410.87069406560.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0565979526
GSE13712_SHEARDown-0.0433865922
GSE13712_STATICDown-0.0683221612
GSE19018Up0.0454808001
GSE19899_A1Up0.0279180066
GSE19899_A2Up0.1714572791
PubMed_21979375_A1Down-0.0015245945
PubMed_21979375_A2Up0.1264558383
GSE35957Up0.1554732313
GSE36640Up0.0535843375
GSE54402Up0.0372059113
GSE9593Up0.0193038374
GSE43922Up0.0158600504
GSE24585Up0.4554768588
GSE37065Up0.0365368901
GSE28863_A1Down-0.2338750211
GSE28863_A2Down-0.0751460118
GSE28863_A3Up0.1648690154
GSE28863_A4Down-0.0034182317
GSE48662Up0.0161318559

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.