HCSGD entry for EIF5
1. General information
| Official gene symbol | EIF5 |
|---|---|
| Entrez ID | 1983 |
| Gene full name | eukaryotic translation initiation factor 5 |
| Other gene symbols | EIF-5 EIF-5A |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003743 | Translation initiation factor activity | IEA NAS | molecular_function |
| GO:0003924 | GTPase activity | TAS | molecular_function |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | NAS TAS | cellular_component |
| GO:0006184 | GTP catabolic process | TAS | biological_process |
| GO:0006412 | Translation | TAS | biological_process |
| GO:0006413 | Translational initiation | NAS TAS | biological_process |
| GO:0006446 | Regulation of translational initiation | TAS | biological_process |
| GO:0008135 | Translation factor activity, nucleic acid binding | TAS | molecular_function |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5434458721 | 0.3793354280 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4568153259 |
| GSE13712_SHEAR | Up | 0.0190950867 |
| GSE13712_STATIC | Down | -0.1470654140 |
| GSE19018 | Down | -0.3399104628 |
| GSE19899_A1 | Down | -0.0585395998 |
| GSE19899_A2 | Down | -0.3401291182 |
| PubMed_21979375_A1 | Up | 0.3500570818 |
| PubMed_21979375_A2 | Down | -0.4618882752 |
| GSE35957 | Up | 0.0119166278 |
| GSE36640 | Down | -0.5842981262 |
| GSE54402 | Up | 0.1905190065 |
| GSE9593 | Down | -0.0787225146 |
| GSE43922 | Down | -0.0159530907 |
| GSE24585 | Up | 0.0576793780 |
| GSE37065 | Up | 0.0747665499 |
| GSE28863_A1 | Up | 0.1810106101 |
| GSE28863_A2 | Up | 0.5037468695 |
| GSE28863_A3 | Down | -0.2418146918 |
| GSE28863_A4 | Up | 0.1183031977 |
| GSE48662 | Down | -0.0987886238 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | MIRT030925 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031742 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045098 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT045909 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
