HCSGD entry for EIF4G1
1. General information
| Official gene symbol | EIF4G1 |
|---|---|
| Entrez ID | 1981 |
| Gene full name | eukaryotic translation initiation factor 4 gamma, 1 |
| Other gene symbols | EIF-4G1 EIF4F EIF4G EIF4GI P220 PARK18 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000184 | Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | TAS | biological_process |
| GO:0000288 | Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | TAS | biological_process |
| GO:0000289 | Nuclear-transcribed mRNA poly(A) tail shortening | TAS | biological_process |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0003743 | Translation initiation factor activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006412 | Translation | TAS | biological_process |
| GO:0006413 | Translational initiation | TAS | biological_process |
| GO:0006446 | Regulation of translational initiation | IMP NAS | biological_process |
| GO:0008135 | Translation factor activity, nucleic acid binding | TAS | molecular_function |
| GO:0008190 | Eukaryotic initiation factor 4E binding | IEA | molecular_function |
| GO:0008219 | Cell death | IEA | biological_process |
| GO:0008286 | Insulin receptor signaling pathway | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0016071 | MRNA metabolic process | TAS | biological_process |
| GO:0016281 | Eukaryotic translation initiation factor 4F complex | IEA | cellular_component |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0030324 | Lung development | IEA | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0045471 | Response to ethanol | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0225927776 | 0.8664554462 | 0.3590567894 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0117007123 |
| GSE13712_SHEAR | Up | 0.3736629617 |
| GSE13712_STATIC | Down | -0.2156815968 |
| GSE19018 | Down | -0.0839878610 |
| GSE19899_A1 | Up | 0.2164366110 |
| GSE19899_A2 | Up | 0.3820864626 |
| PubMed_21979375_A1 | Up | 0.2066990467 |
| PubMed_21979375_A2 | Up | 1.1183818243 |
| GSE35957 | Down | -0.0003881139 |
| GSE36640 | Up | 0.1561269308 |
| GSE54402 | Up | 0.2055385035 |
| GSE9593 | Up | 0.3421160133 |
| GSE43922 | Up | 0.2524615558 |
| GSE24585 | Down | -0.1266009537 |
| GSE37065 | Down | -0.1405133424 |
| GSE28863_A1 | Up | 0.8485777309 |
| GSE28863_A2 | Up | 0.9629997120 |
| GSE28863_A3 | Up | 0.1195273127 |
| GSE28863_A4 | Down | -0.2947912302 |
| GSE48662 | Up | 0.1357292044 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT023744 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025464 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-96-5p | MIMAT0000095 | MIRT027930 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031636 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037651 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-455-3p | MIMAT0004784 | MIRT037839 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040339 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044854 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1260b | MIMAT0015041 | MIRT052684 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
