HCSGD entry for EIF4EBP1
1. General information
| Official gene symbol | EIF4EBP1 |
|---|---|
| Entrez ID | 1978 |
| Gene full name | eukaryotic translation initiation factor 4E binding protein 1 |
| Other gene symbols | 4E-BP1 4EBP1 BP-1 PHAS-I |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | IMP | biological_process |
| GO:0002931 | Response to ischemia | IEA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006412 | Translation | TAS | biological_process |
| GO:0006413 | Translational initiation | TAS | biological_process |
| GO:0008190 | Eukaryotic initiation factor 4E binding | IEA | molecular_function |
| GO:0008286 | Insulin receptor signaling pathway | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0030324 | Lung development | IEA | biological_process |
| GO:0030371 | Translation repressor activity | IDA | molecular_function |
| GO:0031333 | Negative regulation of protein complex assembly | IEA | biological_process |
| GO:0031929 | TOR signaling | IDA | biological_process |
| GO:0043234 | Protein complex | IEA | cellular_component |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0045471 | Response to ethanol | IEA | biological_process |
| GO:0045931 | Positive regulation of mitotic cell cycle | IMP | biological_process |
| GO:0045947 | Negative regulation of translational initiation | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7631509175 | 0.0024748870 | 0.9999902473 | 0.0976634183 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.9212408518 |
| GSE13712_SHEAR | Up | 0.5263317776 |
| GSE13712_STATIC | Up | 0.0529702667 |
| GSE19018 | Up | 0.9788293119 |
| GSE19899_A1 | Down | -0.7070793278 |
| GSE19899_A2 | Down | -0.7347700949 |
| PubMed_21979375_A1 | Up | 0.6483671347 |
| PubMed_21979375_A2 | Down | -1.3185839561 |
| GSE35957 | Down | -1.3861996789 |
| GSE36640 | Down | -1.7677626539 |
| GSE54402 | Up | 0.4976169592 |
| GSE9593 | Down | -0.1580492706 |
| GSE43922 | Down | -0.0936411492 |
| GSE24585 | Down | -0.3652885728 |
| GSE37065 | Down | -0.8417202299 |
| GSE28863_A1 | Down | -0.3204013005 |
| GSE28863_A2 | Down | -0.7284089856 |
| GSE28863_A3 | Up | 0.0643374925 |
| GSE28863_A4 | Down | -0.4260592537 |
| GSE48662 | Down | -0.0932925189 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-125b-5p | MIMAT0000423 | MIRT000347 | Microarray//qRT-PCR | Functional MTI (Weak) | 17891175 |
| hsa-miR-125a-5p | MIMAT0000443 | MIRT021307 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022876 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-125b-5p | MIMAT0000423 | NA | hsa-miR-125b | {immunoblotting} | {overexpression by miRNA mimics tranfection} | 22071331 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23363784 | They all also decreased the level of intracellular ROS and mitochondrial trans-membrane potential DeltaPsim, the marker of mitochondrial energizing as well as reduced phosphorylation of mTOR, RP-S6 and 4EBP1 |
| 21399233 | Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescence |
| 21399233 | Resistance to discodermolide is mediated via resistance to accelerated cell senescence, and is associated with reduced expression of the mTORC1 substrate, 4E-BP1 and increased expression of p53 [1] |
| 21399233 | Furthermore, studies addressing the role of mTOR signaling in regulating senescence have been limited and recent data implicate a novel, senescence-associated role for 4E-BP1 in crosstalk with the transcription factor p53 |
| 21173253 | AD32 cells have decreased levels of 4E-BP1 mRNA and protein, relative to the parental discodermolide-sensitive A549 cells |
| 21173253 | Lentiviral-mediated re-expression of wild-type 4E-BP1 in AD32 cells increased the proliferation rate and reverted resistance to discodermolide via restoration of discodermolide-induced accelerated senescence |
| 21173253 | Furthermore, reintroduction of a nonphosphorylatable mutant (Thr-37/46 Ala) of 4E-BP1 was able to partially restore sensitivity and enhance proliferation in AD32 cells, suggesting that these effects are independent of phosphorylation by mTORC1 |
| 21173253 | Our studies propose a role for 4E-BP1 as a regulator of discodermolide-induced accelerated senescence |
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