HCSGD entry for EIF4B
1. General information
| Official gene symbol | EIF4B |
|---|---|
| Entrez ID | 1975 |
| Gene full name | eukaryotic translation initiation factor 4B |
| Other gene symbols | EIF-4B PRO1843 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0000288 | Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | TAS | biological_process |
| GO:0000289 | Nuclear-transcribed mRNA poly(A) tail shortening | TAS | biological_process |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003723 | RNA binding | TAS | molecular_function |
| GO:0003743 | Translation initiation factor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006412 | Translation | TAS | biological_process |
| GO:0006413 | Translational initiation | TAS | biological_process |
| GO:0006446 | Regulation of translational initiation | TAS | biological_process |
| GO:0008286 | Insulin receptor signaling pathway | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0016071 | MRNA metabolic process | TAS | biological_process |
| GO:0016281 | Eukaryotic translation initiation factor 4F complex | TAS | cellular_component |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8946531211 | 0.0265875727 | 0.9999902473 | 0.3120562834 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3286810200 |
| GSE13712_SHEAR | Down | -0.8470661025 |
| GSE13712_STATIC | Down | -0.9235761888 |
| GSE19018 | Up | 0.2925084670 |
| GSE19899_A1 | Down | -0.1336393245 |
| GSE19899_A2 | Down | -0.0441619339 |
| PubMed_21979375_A1 | Down | -0.5261442369 |
| PubMed_21979375_A2 | Down | -0.1233763027 |
| GSE35957 | Down | -0.1660421506 |
| GSE36640 | Down | -0.4825627604 |
| GSE54402 | Up | 0.0175312374 |
| GSE9593 | Up | 0.2313502141 |
| GSE43922 | Down | -0.2713502538 |
| GSE24585 | Up | 0.0684647068 |
| GSE37065 | Down | -0.3244868308 |
| GSE28863_A1 | Up | 0.3222639267 |
| GSE28863_A2 | Down | -0.6024607210 |
| GSE28863_A3 | Down | -0.0483505917 |
| GSE28863_A4 | Up | 0.1770571303 |
| GSE48662 | Down | -0.0788179420 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016421 | Proteomics | Functional MTI (Weak) | 21512034 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016421 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031710 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031710 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23b-5p | MIMAT0004587 | MIRT038657 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041784 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-3p | MIMAT0001340 | MIRT042549 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045475 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049349 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-25-3p | MIMAT0000081 | MIRT050302 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
