HCSGD entry for MLKL
1. General information
| Official gene symbol | MLKL |
|---|---|
| Entrez ID | 197259 |
| Gene full name | mixed lineage kinase domain-like |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004672 | Protein kinase activity | IEA ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IDA IEA | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0032403 | Protein complex binding | IDA | molecular_function |
| GO:0070207 | Protein homotrimerization | IDA | biological_process |
| GO:0070266 | Necroptotic process | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0003027810 | 0.8681282094 | 0.0467970930 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.7340138325 |
| GSE13712_SHEAR | Up | 0.9581652646 |
| GSE13712_STATIC | Up | 0.9254790739 |
| GSE19018 | Down | -0.2558112153 |
| GSE19899_A1 | Up | 1.2804329904 |
| GSE19899_A2 | Up | 2.9687900316 |
| PubMed_21979375_A1 | Up | 2.9946350287 |
| PubMed_21979375_A2 | Up | 3.4258870981 |
| GSE35957 | Down | -1.4938530394 |
| GSE36640 | Up | 0.5424964425 |
| GSE54402 | Up | 1.9869120497 |
| GSE9593 | Down | -0.2680316895 |
| GSE43922 | Up | 1.9251565048 |
| GSE24585 | Down | -0.1261987494 |
| GSE37065 | Up | 0.7508773260 |
| GSE28863_A1 | Up | 0.0665719805 |
| GSE28863_A2 | Up | 0.1308824160 |
| GSE28863_A3 | Down | -0.2632835261 |
| GSE28863_A4 | Up | 0.1664155178 |
| GSE48662 | Down | -0.5372259947 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
