HCSGD entry for EFNB3
1. General information
| Official gene symbol | EFNB3 |
|---|---|
| Entrez ID | 1949 |
| Gene full name | ephrin-B3 |
| Other gene symbols | EFL6 EPLG8 LERK8 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005005 | Transmembrane-ephrin receptor activity | TAS | molecular_function |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006468 | Protein phosphorylation | TAS | biological_process |
| GO:0007267 | Cell-cell signaling | TAS | biological_process |
| GO:0007399 | Nervous system development | TAS | biological_process |
| GO:0007628 | Adult walking behavior | IEA | biological_process |
| GO:0008152 | Metabolic process | TAS | biological_process |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0016198 | Axon choice point recognition | IEA | biological_process |
| GO:0016310 | Phosphorylation | TAS | biological_process |
| GO:0018108 | Peptidyl-tyrosine phosphorylation | TAS | biological_process |
| GO:0046875 | Ephrin receptor binding | IDA | molecular_function |
| GO:0048013 | Ephrin receptor signaling pathway | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9505212264 | 0.0416798906 | 0.9999902473 | 0.3842519762 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1559491526 |
| GSE13712_SHEAR | Down | -0.1165058809 |
| GSE13712_STATIC | Down | -0.1598989543 |
| GSE19018 | Up | 0.0456733768 |
| GSE19899_A1 | Up | 0.0595236698 |
| GSE19899_A2 | Down | -0.5019551080 |
| PubMed_21979375_A1 | Down | -0.3471214936 |
| PubMed_21979375_A2 | Down | -0.1506414814 |
| GSE35957 | Up | 0.1633830211 |
| GSE36640 | Down | -0.3615042173 |
| GSE54402 | Down | -0.8394767391 |
| GSE9593 | Down | -0.3363511346 |
| GSE43922 | Up | 0.1189005562 |
| GSE24585 | Up | 0.1054157807 |
| GSE37065 | Down | -0.1308651997 |
| GSE28863_A1 | Down | -0.3994879170 |
| GSE28863_A2 | Down | -0.5233984335 |
| GSE28863_A3 | Up | 0.4760805672 |
| GSE28863_A4 | Up | 0.0093111606 |
| GSE48662 | Down | -0.3849292342 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-484 | MIMAT0002174 | MIRT042247 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23303128 | Certain genes were selected and verified by real-time quantitative PCR and, of these genes, robust suppression of Ephrin B3 expression was suggested as a possible cell death-inducing mechanism of combined treatment with IR and PKC 412 |
| 23303128 | Indeed, silencing of Ephrin B3 using siRNA in NSCLC cells resulted in a major alteration of their morphology with an elongated phenotype, decreased proliferation and increased cell death signaling |
| 23303128 | Finally, silencing of Ephrin B3 in combination with IR sensitized U-1810 cells to IR-induced apoptosis |
| 23303128 | In conclusion, we identify and describe Ephrin B3 as a putative signaling molecule involved in the response of NSCLC cells to combined treatment with PKC 412 and ionizing radiation |
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