HCSGD entry for EFNB1
1. General information
| Official gene symbol | EFNB1 |
|---|---|
| Entrez ID | 1947 |
| Gene full name | ephrin-B1 |
| Other gene symbols | CFND CFNS EFL3 EPLG2 Elk-L LERK2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001755 | Neural crest cell migration | IEA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0007155 | Cell adhesion | TAS | biological_process |
| GO:0007267 | Cell-cell signaling | TAS | biological_process |
| GO:0007411 | Axon guidance | IEA | biological_process |
| GO:0009880 | Embryonic pattern specification | IEA | biological_process |
| GO:0042102 | Positive regulation of T cell proliferation | IEA | biological_process |
| GO:0045121 | Membrane raft | IEA | cellular_component |
| GO:0045202 | Synapse | ISS | cellular_component |
| GO:0046875 | Ephrin receptor binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1861819460 | 0.5300159075 | 0.8418291946 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0807815500 |
| GSE13712_SHEAR | Down | -0.4331997873 |
| GSE13712_STATIC | Down | -0.0341705586 |
| GSE19018 | Up | 0.0480307527 |
| GSE19899_A1 | Up | 0.0686944443 |
| GSE19899_A2 | Up | 0.2601272817 |
| PubMed_21979375_A1 | Down | -0.0349531198 |
| PubMed_21979375_A2 | Up | 0.0025528242 |
| GSE35957 | Down | -0.1780966959 |
| GSE36640 | Up | 0.0984683285 |
| GSE54402 | Down | -0.1875546664 |
| GSE9593 | Up | 0.0780748263 |
| GSE43922 | Up | 0.2732998455 |
| GSE24585 | Down | -0.0789320576 |
| GSE37065 | Down | -0.3538685574 |
| GSE28863_A1 | Up | 0.1863506258 |
| GSE28863_A2 | Down | -0.1021373625 |
| GSE28863_A3 | Up | 0.2220714222 |
| GSE28863_A4 | Up | 0.0848201936 |
| GSE48662 | Up | 1.2272245454 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT000478 | qRT-PCR//Luciferase reporter assay//Western blot | Functional MTI | 20308325 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025289 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040525 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT048918 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-204-5p | MIMAT0000265 | NA | hsa-miR-204 | 20369013 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25754370 | Using siRNA to silence expression of key nodes of this network, including ephrins (EFNB1 or 3), PI3Kdelta, p21, BCL-xL, or plasminogen-activated inhibitor-2, killed senescent cells, but not proliferating or quiescent, differentiated cells |
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