HCSGD entry for AGO3
1. General information
| Official gene symbol | AGO3 |
|---|---|
| Entrez ID | 192669 |
| Gene full name | argonaute RISC catalytic component 3 |
| Other gene symbols | EIF2C3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000932 | Cytoplasmic mRNA processing body | IEA | cellular_component |
| GO:0003743 | Translation initiation factor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006402 | MRNA catabolic process | IDA | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007219 | Notch signaling pathway | TAS | biological_process |
| GO:0008543 | Fibroblast growth factor receptor signaling pathway | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016442 | RISC complex | IEA | cellular_component |
| GO:0035068 | Micro-ribonucleoprotein complex | IEA | cellular_component |
| GO:0035198 | MiRNA binding | IEA | molecular_function |
| GO:0035278 | Negative regulation of translation involved in gene silencing by miRNA | IDA | biological_process |
| GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048015 | Phosphatidylinositol-mediated signaling | TAS | biological_process |
| GO:0072091 | Regulation of stem cell proliferation | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0695616542 | 0.6390951712 | 0.5643296148 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0367299020 |
| GSE13712_SHEAR | Up | 0.1206411688 |
| GSE13712_STATIC | Up | 0.2817324195 |
| GSE19018 | Down | -0.2020676100 |
| GSE19899_A1 | Up | 0.2613120382 |
| GSE19899_A2 | Up | 0.0319324116 |
| PubMed_21979375_A1 | Up | 0.0386449657 |
| PubMed_21979375_A2 | Up | 0.4743355514 |
| GSE35957 | Down | -0.1285141683 |
| GSE36640 | Up | 0.1606485490 |
| GSE54402 | Up | 0.0123624647 |
| GSE9593 | Down | -0.0058654786 |
| GSE43922 | Up | 0.0408206666 |
| GSE24585 | Up | 0.2304786332 |
| GSE37065 | Down | -0.0487492729 |
| GSE28863_A1 | Up | 1.2664514940 |
| GSE28863_A2 | Up | 0.9305678403 |
| GSE28863_A3 | Down | -0.7824551605 |
| GSE28863_A4 | Down | -0.3268566563 |
| GSE48662 | Up | 0.1140838130 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | MIRT005037 | Microarray | Functional MTI (Weak) | 17699775 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-129-5p | MIMAT0000242 | NA | hsa-miR-129-5p | 18189265 | |||
| hsa-miR-107 | MIMAT0000104 | NA | hsa-miR-107 | {Western blot} | {overexpression by miRNA precursor transfection} | 20042474 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
