HCSGD entry for EDNRB

1. General information

Official gene symbolEDNRB
Entrez ID1910
Gene full nameendothelin receptor type B
Other gene symbolsABCDS ET-B ET-BR ETB ETBR ETRB HSCR HSCR2 WS4A
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIMP ISSbiological_process
GO:0001755Neural crest cell migrationIEAbiological_process
GO:0001934Positive regulation of protein phosphorylationIEAbiological_process
GO:0004962Endothelin receptor activityIDA IMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006885Regulation of pHIEAbiological_process
GO:0007166Cell surface receptor signaling pathwayTASbiological_process
GO:0007194Negative regulation of adenylate cyclase activityTASbiological_process
GO:0007200Phospholipase C-activating G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationIEAbiological_process
GO:0007399Nervous system developmentTASbiological_process
GO:0007422Peripheral nervous system developmentIEAbiological_process
GO:0007497Posterior midgut developmentIEAbiological_process
GO:0007568AgingIEAbiological_process
GO:0008217Regulation of blood pressureIEAbiological_process
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0014043Negative regulation of neuron maturationISSbiological_process
GO:0014070Response to organic cyclic compoundIEAbiological_process
GO:0014826Vein smooth muscle contractionIMPbiological_process
GO:0017046Peptide hormone bindingIPImolecular_function
GO:0019233Sensory perception of painIEAbiological_process
GO:0019934CGMP-mediated signalingIEAbiological_process
GO:0030318Melanocyte differentiationIEAbiological_process
GO:0031620Regulation of fever generationIEAbiological_process
GO:0031702Type 1 angiotensin receptor bindingIEAmolecular_function
GO:0031965Nuclear membraneIEAcellular_component
GO:0032269Negative regulation of cellular protein metabolic processIMPbiological_process
GO:0035645Enteric smooth muscle cell differentiationISSbiological_process
GO:0035810Positive regulation of urine volumeIEAbiological_process
GO:0035815Positive regulation of renal sodium excretionIEAbiological_process
GO:0042045Epithelial fluid transportIEAbiological_process
GO:0042310VasoconstrictionIMPbiological_process
GO:0042311VasodilationIEAbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0045121Membrane raftIEAcellular_component
GO:0048246Macrophage chemotaxisIMPbiological_process
GO:0048265Response to painIEAbiological_process
GO:0048484Enteric nervous system developmentISSbiological_process
GO:0050678Regulation of epithelial cell proliferationIEAbiological_process
GO:0051930Regulation of sensory perception of painIEAbiological_process
GO:0060406Positive regulation of penile erectionIEAbiological_process
GO:0071222Cellular response to lipopolysaccharideIEAbiological_process
GO:0086100Endothelin receptor signaling pathwayIDA IMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.13360256830.00859868550.73985515360.1849068627

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.0749777193
GSE13712_SHEARDown-4.0381090874
GSE13712_STATICDown-0.6634918935
GSE19018Down-0.2752043777
GSE19899_A1Down-1.5509267260
GSE19899_A2Down-0.9669467809
PubMed_21979375_A1Up0.6712456117
PubMed_21979375_A2Up0.0625004875
GSE35957Up0.0257061160
GSE36640Down-1.4138863414
GSE54402Down-1.0594062188
GSE9593Down-0.7535929548
GSE43922Up0.2612552943
GSE24585Up0.8942868302
GSE37065Up0.7438269953
GSE28863_A1Down-0.1811900223
GSE28863_A2Down-0.0267748264
GSE28863_A3Up0.1953870219
GSE28863_A4Up0.0709300742
GSE48662Up0.0244742435

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

SitaxentanDB06268 -
AmbrisentanDB06403 -
MacitentanDB08932 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

16883569Interestingly, under exposure to subcytotoxic doses of H2O2 (200 microM), about 65% of Chang cells harbored elongated mitochondria with senescent phenotypes whereas ethidium bromide (EtBr) (50 ng/ml) only reformed the cristae structure
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