HCSGD entry for EDN1

1. General information

Official gene symbolEDN1
Entrez ID1906
Gene full nameendothelin 1
Other gene symbolsET1 HDLCQ7 PPET1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0001516Prostaglandin biosynthetic processIDAbiological_process
GO:0001569Patterning of blood vesselsIEAbiological_process
GO:0001666Response to hypoxiaIEAbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001821Histamine secretionIEAbiological_process
GO:0003100Regulation of systemic arterial blood pressure by endothelinIDAbiological_process
GO:0005125Cytokine activityIDAmolecular_function
GO:0005179Hormone activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006885Regulation of pHIEAbiological_process
GO:0007166Cell surface receptor signaling pathwayIDAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationIDAbiological_process
GO:0007205Protein kinase C-activating G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0007267Cell-cell signalingIDAbiological_process
GO:0007507Heart developmentIEAbiological_process
GO:0007585Respiratory gaseous exchangeIEAbiological_process
GO:0007589Body fluid secretionIEAbiological_process
GO:0008284Positive regulation of cell proliferationIDAbiological_process
GO:0009953Dorsal/ventral pattern formationIEAbiological_process
GO:0010259Multicellular organismal agingIEAbiological_process
GO:0010460Positive regulation of heart rateIDAbiological_process
GO:0010595Positive regulation of endothelial cell migrationTASbiological_process
GO:0010613Positive regulation of cardiac muscle hypertrophyIDAbiological_process
GO:0010870Positive regulation of receptor biosynthetic processIDAbiological_process
GO:0014032Neural crest cell developmentIEAbiological_process
GO:0014065Phosphatidylinositol 3-kinase signalingIDAbiological_process
GO:0014824Artery smooth muscle contractionIDA TASbiological_process
GO:0014826Vein smooth muscle contractionIDAbiological_process
GO:0015758Glucose transportIEAbiological_process
GO:0016049Cell growthIEAbiological_process
GO:0019229Regulation of vasoconstrictionIEAbiological_process
GO:0019233Sensory perception of painIEAbiological_process
GO:0019722Calcium-mediated signalingIDAbiological_process
GO:0030072Peptide hormone secretionIDAbiological_process
GO:0030185Nitric oxide transportIDAbiological_process
GO:0030195Negative regulation of blood coagulationTASbiological_process
GO:0030335Positive regulation of cell migrationIDAbiological_process
GO:0030593Neutrophil chemotaxisIDAbiological_process
GO:0030818Negative regulation of cAMP biosynthetic processIEAbiological_process
GO:0031583Phospholipase D-activating G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0031707Endothelin A receptor bindingIDAmolecular_function
GO:0031708Endothelin B receptor bindingIDAmolecular_function
GO:0032269Negative regulation of cellular protein metabolic processIDAbiological_process
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0033574Response to testosteroneIEAbiological_process
GO:0034392Negative regulation of smooth muscle cell apoptotic processIEAbiological_process
GO:0035094Response to nicotineIEAbiological_process
GO:0035810Positive regulation of urine volumeIEAbiological_process
GO:0035815Positive regulation of renal sodium excretionIEAbiological_process
GO:0042045Epithelial fluid transportIEAbiological_process
GO:0042310VasoconstrictionIDAbiological_process
GO:0042313Protein kinase C deactivationIDAbiological_process
GO:0042474Middle ear morphogenesisIEAbiological_process
GO:0042482Positive regulation of odontogenesisIEAbiological_process
GO:0042554Superoxide anion generationIEAbiological_process
GO:0043179Rhythmic excitationIEAbiological_process
GO:0043200Response to amino acidIEAbiological_process
GO:0043406Positive regulation of MAP kinase activityIDAbiological_process
GO:0043507Positive regulation of JUN kinase activityIDAbiological_process
GO:0045321Leukocyte activationTASbiological_process
GO:0045429Positive regulation of nitric oxide biosynthetic processTASbiological_process
GO:0045793Positive regulation of cell sizeIDAbiological_process
GO:0045840Positive regulation of mitosisIDAbiological_process
GO:0045987Positive regulation of smooth muscle contractionIEAbiological_process
GO:0046887Positive regulation of hormone secretionIDAbiological_process
GO:0046888Negative regulation of hormone secretionIEAbiological_process
GO:0048016Inositol phosphate-mediated signalingIDAbiological_process
GO:0048661Positive regulation of smooth muscle cell proliferationIDAbiological_process
GO:0051216Cartilage developmentIEAbiological_process
GO:0051482Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayIEAbiological_process
GO:0051771Negative regulation of nitric-oxide synthase biosynthetic processIDAbiological_process
GO:0051899Membrane depolarizationIEAbiological_process
GO:0051930Regulation of sensory perception of painIEAbiological_process
GO:0060137Maternal process involved in parturitionIEAbiological_process
GO:0060298Positive regulation of sarcomere organizationIMPbiological_process
GO:0060585Positive regulation of prostaglandin-endoperoxide synthase activityIMPbiological_process
GO:0070101Positive regulation of chemokine-mediated signaling pathwayICbiological_process
GO:0071347Cellular response to interleukin-1IEAbiological_process
GO:0071356Cellular response to tumor necrosis factorIEAbiological_process
GO:0090023Positive regulation of neutrophil chemotaxisIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00289545990.13237835950.14433043480.7009315631

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-1.3118838401
GSE13712_SHEARUp0.5097074771
GSE13712_STATICUp0.0160723813
GSE19018Up0.1976719006
GSE19899_A1Up0.3112478745
GSE19899_A2Up2.5170985139
PubMed_21979375_A1Up2.2793786266
PubMed_21979375_A2Up2.4292813636
GSE35957Up2.0528211004
GSE36640Up1.7557554215
GSE54402Up1.3113165558
GSE9593Up0.0143654982
GSE43922Up0.4172828930
GSE24585Down-0.4091109123
GSE37065Down-0.1939613451
GSE28863_A1Down-0.8988161624
GSE28863_A2Down-0.2845442041
GSE28863_A3Down-0.0455321512
GSE28863_A4Down-0.2571291716
GSE48662Down-0.0275458603

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

TBC-3711DB05407 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT004455Luciferase reporter assayFunctional MTI19783678
hsa-miR-199a-5pMIMAT0000231MIRT005432Luciferase reporter assayFunctional MTI19783678
hsa-miR-1MIMAT0000416MIRT006855Luciferase reporter assayFunctional MTI22963810
hsa-miR-1MIMAT0000416MIRT006855MicroarrayFunctional MTI (Weak)18668037
hsa-miR-124-3pMIMAT0000422MIRT022267MicroarrayFunctional MTI (Weak)18668037
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25239727ET-1 - the biologically predominant member of the endothelin peptide family - is an endothelial cell-derived peptide with a wide variety of developmental and physiological functions, which include embryogenesis, nociception, and natriuresis
25239727In addition, ET-1 is a cytokine-like, multifunctional peptide with pro-inflammatory, mitogenic, and vasoconstrictor properties
25239727If produced in excess amounts ET-1 promotes disease - mainly via activation of its ETA receptor
25239727Because of its multiple disease-promoting functions ET-1 represents an ideal target MMM
25239727Preclinical studies targeting either activity or production of ET-1 - utilizing ERAs, ARBs, or ACEIs, respectively - have demonstrated that partial regression of aging-associated changes in vasculature and kidney is possible
25239727In this article I will review the molecular regulation of ET-1 and its role in the physiology of vascular homeostasis, aging, and cellular senescence
25239727The clinical implications of activators of ET-1 overproduction, modalities for delaying or reversing aging-related cellular changes, as well as interventions to promote healthy aging and early disease prevention - particularly physical activity - are discussed
22521293ETS-dependent p16INK4a and p21waf1/cip1 gene expression upon endothelin-1 stimulation in malignant versus and non-malignant proximal tubule cells
22521293While in both conditions endothelin-1 is also upregulated, the signaling pathway connecting ET-1 to p16(INK4a) has not been characterized until this study
22521293In contrast, primary proximal tubule cells showed a nuclear decrease after ET-1 stimulation
16280018CONCLUSIONS: These findings suggest that IL-1alpha secretion increases as cells grow older, and the increased secretion of IL-1alpha by aged keratinocytes may stimulate HGF production in dermal fibroblasts paracrinely and ET-1 production in keratinocytes autocrinely, which stimulates melanocyte proliferation and induces an increase of tyrosinase activity in melanocytes
12759390RESULTS: Both melanocyte cultures showed high rates of apoptosis, which were reduced when the cells were grown in the presence of keratinocyte feeder cells or human stem cell factor plus endothelin 1
11668329Interleukin-8 and endothelin-1 were demonstrated by means of the microarray to be differentially expressed more than twofold in VSMCs that were exposed to ApoJ
8253603The results showed that the expression of ET-1 gene was also up-regulated when the culture became old
8253603It is very interesting that the genes for quite different proteins of FN and ET-1 are both up-regulated during cellular aging
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