HCSGD entry for ECT2
1. General information
| Official gene symbol | ECT2 |
|---|---|
| Entrez ID | 1894 |
| Gene full name | epithelial cell transforming sequence 2 oncogene |
| Other gene symbols | ARHGEF31 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000902 | Cell morphogenesis | IEA | biological_process |
| GO:0000910 | Cytokinesis | IEA IMP | biological_process |
| GO:0004871 | Signal transducer activity | IMP | molecular_function |
| GO:0005085 | Guanyl-nucleotide exchange factor activity | IEA | molecular_function |
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | IDA IEA | molecular_function |
| GO:0005096 | GTPase activator activity | IEA IMP | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005911 | Cell-cell junction | IDA | cellular_component |
| GO:0005923 | Tight junction | IDA | cellular_component |
| GO:0007264 | Small GTPase mediated signal transduction | TAS | biological_process |
| GO:0015031 | Protein transport | IEA | biological_process |
| GO:0017048 | Rho GTPase binding | IEA | molecular_function |
| GO:0030496 | Midbody | IDA | cellular_component |
| GO:0032147 | Activation of protein kinase activity | IDA | biological_process |
| GO:0032154 | Cleavage furrow | IDA | cellular_component |
| GO:0032321 | Positive regulation of Rho GTPase activity | IDA IMP | biological_process |
| GO:0032467 | Positive regulation of cytokinesis | IDA IMP | biological_process |
| GO:0032862 | Activation of Rho GTPase activity | IDA | biological_process |
| GO:0032863 | Activation of Rac GTPase activity | IMP | biological_process |
| GO:0035556 | Intracellular signal transduction | IEA | biological_process |
| GO:0042307 | Positive regulation of protein import into nucleus | IEA ISS | biological_process |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0043065 | Positive regulation of apoptotic process | IDA TAS | biological_process |
| GO:0043089 | Positive regulation of Cdc42 GTPase activity | IDA | biological_process |
| GO:0043123 | Positive regulation of I-kappaB kinase/NF-kappaB signaling | IMP | biological_process |
| GO:0045666 | Positive regulation of neuron differentiation | IEA ISS | biological_process |
| GO:0045859 | Regulation of protein kinase activity | IDA | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0051056 | Regulation of small GTPase mediated signal transduction | TAS | biological_process |
| GO:0051260 | Protein homooligomerization | IDA | biological_process |
| GO:0051988 | Regulation of attachment of spindle microtubules to kinetochore | IMP | biological_process |
| GO:0070301 | Cellular response to hydrogen peroxide | IDA | biological_process |
| GO:0070830 | Tight junction assembly | IMP | biological_process |
| GO:0071277 | Cellular response to calcium ion | IDA | biological_process |
| GO:0071479 | Cellular response to ionizing radiation | IDA | biological_process |
| GO:0072686 | Mitotic spindle | IDA | cellular_component |
| GO:0097149 | Centralspindlin complex | IDA | cellular_component |
| GO:0097190 | Apoptotic signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7247636640 | 0.0102737586 | 0.9999902473 | 0.2003078519 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3377811822 |
| GSE13712_SHEAR | Up | 0.4093282133 |
| GSE13712_STATIC | Down | -0.0152499477 |
| GSE19018 | Up | 0.4214678749 |
| GSE19899_A1 | Up | 0.0098824427 |
| GSE19899_A2 | Down | -1.2365825495 |
| PubMed_21979375_A1 | Down | -0.1522197214 |
| PubMed_21979375_A2 | Down | -0.7791468088 |
| GSE35957 | Down | -0.7422732012 |
| GSE36640 | Down | -1.9198551595 |
| GSE54402 | Down | -0.6044936435 |
| GSE9593 | Down | -0.3198821575 |
| GSE43922 | Down | -0.0000305039 |
| GSE24585 | Up | 0.0692362465 |
| GSE37065 | Up | 0.0743352432 |
| GSE28863_A1 | Down | -0.3521881837 |
| GSE28863_A2 | Up | 1.2972438915 |
| GSE28863_A3 | Down | -0.3940984553 |
| GSE28863_A4 | Down | -0.0658071128 |
| GSE48662 | Down | -1.1622207374 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016363 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-132-3p | MIMAT0000426 | MIRT021839 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024659 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026504 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-96-5p | MIMAT0000095 | MIRT027900 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-27a-3p | MIMAT0000084 | MIRT028718 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029452 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047830 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
