HCSGD entry for ECE1

1. General information

Official gene symbolECE1
Entrez ID1889
Gene full nameendothelin converting enzyme 1
Other gene symbolsECE
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001921Positive regulation of receptor recyclingIMPbiological_process
GO:0003100Regulation of systemic arterial blood pressure by endothelinICbiological_process
GO:0004175Endopeptidase activityIDAmolecular_function
GO:0004222Metalloendopeptidase activityIEA ISSmolecular_function
GO:0005765Lysosomal membraneIDAcellular_component
GO:0005768EndosomeIDAcellular_component
GO:0005769Early endosomeIDAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006508ProteolysisIEAbiological_process
GO:0007507Heart developmentIMPbiological_process
GO:0009897External side of plasma membraneIDAcellular_component
GO:0010814Substance P catabolic processIDAbiological_process
GO:0010815Bradykinin catabolic processIDAbiological_process
GO:0010816Calcitonin catabolic processIDAbiological_process
GO:0016021Integral component of membraneIDAcellular_component
GO:0016485Protein processingIDAbiological_process
GO:0016486Peptide hormone processingIDAbiological_process
GO:0017046Peptide hormone bindingICmolecular_function
GO:0019229Regulation of vasoconstrictionICbiological_process
GO:0031302Intrinsic component of endosome membraneTAScellular_component
GO:0031982VesicleISScellular_component
GO:0033093Weibel-Palade bodyIDAcellular_component
GO:0034959Endothelin maturationIDAbiological_process
GO:0042447Hormone catabolic processIDAbiological_process
GO:0042733Embryonic digit morphogenesisIMPbiological_process
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0043583Ear developmentIMPbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0060037Pharyngeal system developmentIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02236960980.84931151930.35731673741.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2980855132
GSE13712_SHEARDown-0.1178746955
GSE13712_STATICDown-0.4890162087
GSE19018Up0.5968326841
GSE19899_A1Up0.0825119959
GSE19899_A2Up0.9651900448
PubMed_21979375_A1Up0.2771299493
PubMed_21979375_A2Up0.2899227436
GSE35957Up0.0820593233
GSE36640Up0.1140874377
GSE54402Up0.0516508534
GSE9593Down-0.0741989585
GSE43922Up0.3900558223
GSE24585Up0.2508737589
GSE37065Up0.1152795627
GSE28863_A1Up0.7110291189
GSE28863_A2Up0.7355865551
GSE28863_A3Down-0.1102838181
GSE28863_A4Down-0.1268643204
GSE48662Up0.4083430979

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

5-(2-hydroxyethyl)nonane-1,9-diolDB07171 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT016794MicroarrayFunctional MTI (Weak)18185580
hsa-miR-124-3pMIMAT0000422MIRT022165MicroarrayFunctional MTI (Weak)18668037
hsa-miR-484MIMAT0002174MIRT042082CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.