HCSGD entry for E2F4
1. General information
| Official gene symbol | E2F4 |
|---|---|
| Entrez ID | 1874 |
| Gene full name | E2F transcription factor 4, p107/p130-binding |
| Other gene symbols | E2F-4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000083 | Regulation of transcription involved in G1/S transition of mitotic cell cycle | IEA | biological_process |
| GO:0000278 | Mitotic cell cycle | IEA TAS | biological_process |
| GO:0002064 | Epithelial cell development | IEA | biological_process |
| GO:0003677 | DNA binding | IEA IMP | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005667 | Transcription factor complex | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA TAS | biological_process |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0006884 | Cell volume homeostasis | IEA | biological_process |
| GO:0007179 | Transforming growth factor beta receptor signaling pathway | TAS | biological_process |
| GO:0008015 | Blood circulation | IEA | biological_process |
| GO:0008134 | Transcription factor binding | IPI | molecular_function |
| GO:0008361 | Regulation of cell size | IEA | biological_process |
| GO:0009887 | Organ morphogenesis | IEA | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0019904 | Protein domain specific binding | IPI | molecular_function |
| GO:0042127 | Regulation of cell proliferation | IEA | biological_process |
| GO:0042384 | Cilium assembly | IEA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4050086547 | 0.5530824323 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0254057936 |
| GSE13712_SHEAR | Up | 0.0524551712 |
| GSE13712_STATIC | Down | -0.0827385160 |
| GSE19018 | Down | -0.2587117303 |
| GSE19899_A1 | Down | -0.0664535865 |
| GSE19899_A2 | Up | 0.2137525496 |
| PubMed_21979375_A1 | Up | 1.0657679139 |
| PubMed_21979375_A2 | Up | 0.4512782499 |
| GSE35957 | Up | 0.0957061460 |
| GSE36640 | Down | -0.0998823989 |
| GSE54402 | Up | 0.3010681317 |
| GSE9593 | Down | -0.0036439961 |
| GSE43922 | Up | 0.1905066966 |
| GSE24585 | Down | -0.5388511915 |
| GSE37065 | Down | -0.0777073044 |
| GSE28863_A1 | Down | -0.0622204789 |
| GSE28863_A2 | Up | 0.1638158551 |
| GSE28863_A3 | Down | -0.4692665345 |
| GSE28863_A4 | Up | 0.0322407242 |
| GSE48662 | Up | 0.0845428863 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022270 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039886 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT046375 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-197-3p | MIMAT0000227 | MIRT048137 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT048712 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22002537 | Recruitment of PML to the TBX2 promoter is dependent on a functional p130/E2F4 repressor complex ultimately implementing a transcriptionally inactive chromatin environment at the TBX2 promoter |
| 10585280 | Here we present evidence that activation of a cAMP pathway correlates with multiple cellular changes in these cells: (1) increased expression of the transcription factor microphthalmia; (2) increased melanogenesis; (3) increased association of the cyclin-dependent kinase inhibitors (CDK-Is) p27(KIP1) and p16(INK4) with CDK2 and CDK4, respectively; (4) failure to phosphorylate the retinoblastoma protein (pRB); (5) decreased expression of E2F1, E2F2, and E2F4 proteins; (6) loss of E2F DNA-binding activity; and (7) phenotypic changes characteristic of senescent cells |
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