HCSGD entry for E2F2
1. General information
| Official gene symbol | E2F2 |
|---|---|
| Entrez ID | 1870 |
| Gene full name | E2F transcription factor 2 |
| Other gene symbols | E2F-2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0001047 | Core promoter binding | IDA | molecular_function |
| GO:0003677 | DNA binding | TAS | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005667 | Transcription factor complex | IEA | cellular_component |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0008134 | Transcription factor binding | IPI | molecular_function |
| GO:0051726 | Regulation of cell cycle | IEA | biological_process |
| GO:0072332 | Intrinsic apoptotic signaling pathway by p53 class mediator | IEA | biological_process |
| GO:1990086 | Lens fiber cell apoptotic process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9692373846 | 0.0559891455 | 0.9999902473 | 0.4446561388 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0680039174 |
| GSE13712_SHEAR | Down | -0.1880925657 |
| GSE13712_STATIC | Down | -0.2294529459 |
| GSE19018 | Up | 0.0062463974 |
| GSE19899_A1 | Down | -0.0108411934 |
| GSE19899_A2 | Down | -0.2639106094 |
| PubMed_21979375_A1 | Down | -0.4377436113 |
| PubMed_21979375_A2 | Down | -0.1947203624 |
| GSE35957 | Down | -0.0810038791 |
| GSE36640 | Down | -1.2979742432 |
| GSE54402 | Down | -0.1808079053 |
| GSE9593 | Down | -0.0064966833 |
| GSE43922 | Up | 0.0749088778 |
| GSE24585 | Up | 0.1428034989 |
| GSE37065 | Down | -0.1289189598 |
| GSE28863_A1 | Down | -0.1740163115 |
| GSE28863_A2 | Up | 0.2769303702 |
| GSE28863_A3 | Up | 0.1909901777 |
| GSE28863_A4 | Up | 0.0383916426 |
| GSE48662 | Down | -2.0303966798 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-24-3p | MIMAT0000080 | MIRT000122 | Luciferase reporter assay//Microarray//qRT-PCR//Western blot//Western blot;qRT-PCR;Microarray;Other | Functional MTI | 19748357 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT001121 | Northern blot//qRT-PCR//ChIP | Functional MTI (Weak) | 19528081 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT001126 | Northern blot//Western blot//qRT-PCR//ChIP//Luciferase reporter assay | Functional MTI | 19528081 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT005477 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20418948 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT006974 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 22999819 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016577 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT021062 | Reporter assay;Other | Functional MTI | 20584899 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT021062 | Reporter assay;Other | Non-Functional MTI | 19759154 |
| hsa-miR-22-3p | MIMAT0000077 | MIRT030648 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043574 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT047757 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-24-3p | MIMAT0000080 | 1 | hsa-miR-24 | {Western blot} | {overexpression by miRNA mimics tranfection} | 19748357 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27081696 | Serial gene expression analyses with SK-Hep1 liver cancer cells treated with JQ1 to delineate the key player of BRD4 inhibition identified E2F2 as the first line of downstream direct target of BRD4 |
| 27081696 | Further experiments including chromatin immunoprecipitation (ChIP) assay and loss of function study confirmed E2F2 as key player of BRD4 inhibition |
| 25772242 | We show that MOZ is required to maintain normal levels of histone 3 lysine 9 (H3K9) and H3K27 acetylation at the transcriptional start sites of at least four genes, Cdc6, Ezh2, E2f2 and Melk, and normal mRNA levels of these genes |
| 25772242 | CDC6, EZH2 and E2F2 are known inhibitors of the INK4A-ARF pathway |
| 11640890 | Expression by recombinant adenovirus of E2F1, E2F2, E2F3, cyclin E/cdk2, and Mdm2 individually resulted in DNA synthesis in 10-30% of cells |
| 10585280 | Here we present evidence that activation of a cAMP pathway correlates with multiple cellular changes in these cells: (1) increased expression of the transcription factor microphthalmia; (2) increased melanogenesis; (3) increased association of the cyclin-dependent kinase inhibitors (CDK-Is) p27(KIP1) and p16(INK4) with CDK2 and CDK4, respectively; (4) failure to phosphorylate the retinoblastoma protein (pRB); (5) decreased expression of E2F1, E2F2, and E2F4 proteins; (6) loss of E2F DNA-binding activity; and (7) phenotypic changes characteristic of senescent cells |
| 8816912 | In contrast, E2F-2 mRNA was not detectable in IMR-90 or WI-38 human fibroblasts |
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