HCSGD entry for DUT
1. General information
| Official gene symbol | DUT |
|---|---|
| Entrez ID | 1854 |
| Gene full name | deoxyuridine triphosphatase |
| Other gene symbols | dUTPase |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004170 | DUTP diphosphatase activity | EXP IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | TAS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0006139 | Nucleobase-containing compound metabolic process | TAS | biological_process |
| GO:0006206 | Pyrimidine nucleobase metabolic process | TAS | biological_process |
| GO:0006226 | DUMP biosynthetic process | IEA | biological_process |
| GO:0006260 | DNA replication | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046080 | DUTP metabolic process | IEA | biological_process |
| GO:0046134 | Pyrimidine nucleoside biosynthetic process | TAS | biological_process |
| GO:0055086 | Nucleobase-containing small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9919102276 | 0.0007498043 | 0.9999902473 | 0.0515289817 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3759382821 |
| GSE13712_SHEAR | Down | -0.0588865324 |
| GSE13712_STATIC | Down | -0.4524609368 |
| GSE19018 | Up | 0.0560156971 |
| GSE19899_A1 | Down | -1.4637082125 |
| GSE19899_A2 | Down | -2.0121907542 |
| PubMed_21979375_A1 | Down | -2.5386125028 |
| PubMed_21979375_A2 | Down | -2.4830926298 |
| GSE35957 | Down | -0.9980644306 |
| GSE36640 | Down | -2.3454107768 |
| GSE54402 | Down | -0.6815405204 |
| GSE9593 | Down | -0.5975636950 |
| GSE43922 | Down | -0.9210437178 |
| GSE24585 | Down | -0.3205023569 |
| GSE37065 | Down | -0.0361382541 |
| GSE28863_A1 | Up | 0.0667728014 |
| GSE28863_A2 | Up | 0.2493537754 |
| GSE28863_A3 | Down | -0.5184032863 |
| GSE28863_A4 | Up | 0.2752411007 |
| GSE48662 | Down | -0.1317146642 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Deoxyuridine-5'-Diphosphate | DB03413 | EXPT01297 |
| 1-{(2S,5S)-4-FLUORO-5-[(TRITYLOXY)METHYL]TETRAHYDROFURAN-2-YL}PYRIMIDINE-2,4(1H,3H)-DIONE | DB04685 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016364 | Proteomics | Functional MTI (Weak) | 21512034 |
| hsa-miR-375 | MIMAT0000728 | MIRT019818 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025455 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029453 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-1226-3p | MIMAT0005577 | MIRT036432 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037723 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 8077291 | The enzymes encoded by TS and DHFR genes and dUTPase also exhibited similar age-dependent attenuation in activities |
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