HCSGD entry for DUSP7

1. General information

Official gene symbolDUSP7
Entrez ID1849
Gene full namedual specificity phosphatase 7
Other gene symbolsMKPX PYST2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000188Inactivation of MAPK activityIBAbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0004725Protein tyrosine phosphatase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005829CytosolIDAcellular_component
GO:0006470Protein dephosphorylationIEAbiological_process
GO:0017017MAP kinase tyrosine/serine/threonine phosphatase activityIDA IEAmolecular_function
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0035335Peptidyl-tyrosine dephosphorylationIDAbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0043407Negative regulation of MAP kinase activityIDAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0051403Stress-activated MAPK cascadeTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.79390084720.12863643480.99999024730.6903842813

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2016121974
GSE13712_SHEARUp0.6951778277
GSE13712_STATICUp0.2518289604
GSE19018Down-0.6699639955
GSE19899_A1Down-0.0462053610
GSE19899_A2Up0.1768178234
PubMed_21979375_A1Down-0.0015142633
PubMed_21979375_A2Up0.0380446903
GSE35957Up0.1662751940
GSE36640Down-0.1211327866
GSE54402Up0.0058745441
GSE9593Down-0.1204095006
GSE43922Down-0.0416916753
GSE24585Down-0.3093355019
GSE37065Down-0.1413803746
GSE28863_A1Down-0.3213165102
GSE28863_A2Up0.2517285973
GSE28863_A3Down-0.0000249159
GSE28863_A4Down-0.3027936010
GSE48662Up0.0278269471

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029270MicroarrayFunctional MTI (Weak)19088304
hsa-miR-760MIMAT0004957MIRT036734CLASHFunctional MTI (Weak)23622248
hsa-let-7c-5pMIMAT0000064MIRT051779CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.