HCSGD entry for DUSP2
1. General information
| Official gene symbol | DUSP2 |
|---|---|
| Entrez ID | 1844 |
| Gene full name | dual specificity phosphatase 2 |
| Other gene symbols | PAC-1 PAC1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000188 | Inactivation of MAPK activity | IBA | biological_process |
| GO:0001706 | Endoderm formation | IBA | biological_process |
| GO:0004725 | Protein tyrosine phosphatase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | TAS | cellular_component |
| GO:0005654 | Nucleoplasm | IBA | cellular_component |
| GO:0006470 | Protein dephosphorylation | IBA | biological_process |
| GO:0008330 | Protein tyrosine/threonine phosphatase activity | TAS | molecular_function |
| GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity | IBA | molecular_function |
| GO:0035335 | Peptidyl-tyrosine dephosphorylation | TAS | biological_process |
| GO:0042981 | Regulation of apoptotic process | IBA | biological_process |
| GO:0051019 | Mitogen-activated protein kinase binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3229996429 | 0.0975247673 | 0.9999902473 | 0.5962716376 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -3.0337218604 |
| GSE13712_SHEAR | Down | -0.1171216743 |
| GSE13712_STATIC | Down | -0.1218310637 |
| GSE19018 | Down | -0.1669097805 |
| GSE19899_A1 | Up | 0.2388607247 |
| GSE19899_A2 | Up | 0.4468311109 |
| PubMed_21979375_A1 | Down | -0.0877873092 |
| PubMed_21979375_A2 | Up | 0.6705055887 |
| GSE35957 | Up | 0.7063486323 |
| GSE36640 | Up | 0.1825016114 |
| GSE54402 | Up | 0.2008132690 |
| GSE9593 | Down | -0.2806974679 |
| GSE43922 | Up | 0.1893058136 |
| GSE24585 | Up | 0.1554825729 |
| GSE37065 | Down | -0.1264371431 |
| GSE28863_A1 | Down | -0.4734323623 |
| GSE28863_A2 | Down | -0.4083722512 |
| GSE28863_A3 | Down | -0.1585140938 |
| GSE28863_A4 | Up | 0.1719977837 |
| GSE48662 | Down | -0.3038795364 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-122-5p | MIMAT0000421 | MIRT003094 | Luciferase reporter assay//qRT-PCR | Functional MTI | 19296470 |
| hsa-miR-29b-3p | MIMAT0000100 | MIRT007102 | Luciferase reporter assay | Functional MTI | 23478036 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT023093 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
