HCSGD entry for DTX1
1. General information
| Official gene symbol | DTX1 |
|---|---|
| Entrez ID | 1840 |
| Gene full name | deltex homolog 1 (Drosophila) |
| Other gene symbols | hDx-1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003713 | Transcription coactivator activity | TAS | molecular_function |
| GO:0005112 | Notch binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | NAS | biological_process |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0007166 | Cell surface receptor signaling pathway | TAS | biological_process |
| GO:0007219 | Notch signaling pathway | TAS | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0008593 | Regulation of Notch signaling pathway | IGI | biological_process |
| GO:0010001 | Glial cell differentiation | IEA | biological_process |
| GO:0016567 | Protein ubiquitination | IEA | biological_process |
| GO:0016874 | Ligase activity | IEA | molecular_function |
| GO:0017124 | SH3 domain binding | IEA | molecular_function |
| GO:0031625 | Ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0045581 | Negative regulation of T cell differentiation | IEA | biological_process |
| GO:0045665 | Negative regulation of neuron differentiation | IGI | biological_process |
| GO:2001141 | Regulation of RNA biosynthetic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8250347783 | 0.7197155085 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2115276154 |
| GSE13712_SHEAR | Down | -0.1213368716 |
| GSE13712_STATIC | Down | -0.1380928134 |
| GSE19018 | Up | 0.0392608389 |
| GSE19899_A1 | Down | -0.1020471067 |
| GSE19899_A2 | Down | -0.0009632622 |
| PubMed_21979375_A1 | Up | 0.3745710452 |
| PubMed_21979375_A2 | Down | -0.0580913905 |
| GSE35957 | Up | 0.2356544197 |
| GSE36640 | Down | -0.0545275064 |
| GSE54402 | Up | 0.1915330661 |
| GSE9593 | Down | -0.1607416832 |
| GSE43922 | Up | 0.0891804599 |
| GSE24585 | Down | -0.0426572397 |
| GSE37065 | Up | 0.0356818443 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.0312889574 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017334 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-1 | MIMAT0000416 | MIRT023569 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
