HCSGD entry for RCAN1
1. General information
| Official gene symbol | RCAN1 |
|---|---|
| Entrez ID | 1827 |
| Gene full name | regulator of calcineurin 1 |
| Other gene symbols | ADAPT78 CSP1 DSC1 DSCR1 MCIP1 RCN1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | TAS | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006355 | Regulation of transcription, DNA-templated | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007417 | Central nervous system development | TAS | biological_process |
| GO:0008015 | Blood circulation | TAS | biological_process |
| GO:0009612 | Response to mechanical stimulus | IEA | biological_process |
| GO:0019722 | Calcium-mediated signaling | IEA | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0043627 | Response to estrogen | IEA | biological_process |
| GO:0043666 | Regulation of phosphoprotein phosphatase activity | IEA | biological_process |
| GO:0048741 | Skeletal muscle fiber development | IEA | biological_process |
| GO:0051151 | Negative regulation of smooth muscle cell differentiation | IEA | biological_process |
| GO:2001141 | Regulation of RNA biosynthetic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5555621671 | 0.0298223358 | 0.9999902473 | 0.3263840748 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.8330211138 |
| GSE13712_SHEAR | Down | -0.2811522432 |
| GSE13712_STATIC | Down | -0.0030920101 |
| GSE19018 | Down | -0.3707570710 |
| GSE19899_A1 | Down | -0.6801654280 |
| GSE19899_A2 | Down | -0.2160915256 |
| PubMed_21979375_A1 | Up | 0.6555697178 |
| PubMed_21979375_A2 | Down | -1.8645024419 |
| GSE35957 | Up | 0.4359582094 |
| GSE36640 | Up | 0.7564630772 |
| GSE54402 | Down | -0.4329882341 |
| GSE9593 | Up | 0.8321117697 |
| GSE43922 | Down | -0.3238747239 |
| GSE24585 | Down | -0.1881084299 |
| GSE37065 | Down | -0.0873084296 |
| GSE28863_A1 | Down | -0.0737733973 |
| GSE28863_A2 | Down | -0.0122685257 |
| GSE28863_A3 | Up | 0.4228771681 |
| GSE28863_A4 | Up | 0.0116529558 |
| GSE48662 | Down | -0.0006265163 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | MIRT005055 | Microarray | Functional MTI (Weak) | 17699775 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018955 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT023116 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049031 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
