HCSGD entry for JAG1

1. General information

Official gene symbolJAG1
Entrez ID182
Gene full namejagged 1
Other gene symbolsAGS AHD AWS CD339 HJ1 JAGL1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001525AngiogenesisNASbiological_process
GO:0001709Cell fate determinationNASbiological_process
GO:0002011Morphogenesis of an epithelial sheetIEAbiological_process
GO:0003184Pulmonary valve morphogenesisIMPbiological_process
GO:0003215Cardiac right ventricle morphogenesisIEA ISSbiological_process
GO:0005112Notch bindingIEA NASmolecular_function
GO:0005198Structural molecule activityNASmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionNAScellular_component
GO:0005886Plasma membraneIDA IEA TAScellular_component
GO:0005887Integral component of plasma membraneNAScellular_component
GO:0007219Notch signaling pathwayIMP NAS TASbiological_process
GO:0007220Notch receptor processingTASbiological_process
GO:0007399Nervous system developmentNASbiological_process
GO:0008083Growth factor activityNASmolecular_function
GO:0016020MembraneTAScellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0030097HemopoiesisNASbiological_process
GO:0030216Keratinocyte differentiationNASbiological_process
GO:0030334Regulation of cell migrationNASbiological_process
GO:0032495Response to muramyl dipeptideIEAbiological_process
GO:0035909Aorta morphogenesisIEA ISSbiological_process
GO:0042127Regulation of cell proliferationNASbiological_process
GO:0042491Auditory receptor cell differentiationIEAbiological_process
GO:0045177Apical part of cellIEAcellular_component
GO:0045445Myoblast differentiationNASbiological_process
GO:0045446Endothelial cell differentiationNASbiological_process
GO:0045599Negative regulation of fat cell differentiationIEAbiological_process
GO:0045639Positive regulation of myeloid cell differentiationIEAbiological_process
GO:0045665Negative regulation of neuron differentiationIEAbiological_process
GO:0045747Positive regulation of Notch signaling pathwayIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEA IMPbiological_process
GO:0060411Cardiac septum morphogenesisIEA ISSbiological_process
GO:0061156Pulmonary artery morphogenesisIMPbiological_process
GO:0061309Cardiac neural crest cell development involved in outflow tract morphogenesisIEA ISSbiological_process
GO:0061314Notch signaling involved in heart developmentIC IEA IMPbiological_process
GO:0061444Endocardial cushion cell developmentIEA ISSbiological_process
GO:0072017Distal tubule developmentIEAbiological_process
GO:0072070Loop of Henle developmentIEAbiological_process
GO:0097150Neuronal stem cell maintenanceIEPbiological_process
GO:2000737Negative regulation of stem cell differentiationIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02214527180.41584458420.35641662591.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.5956566339
GSE13712_SHEARUp0.1294248876
GSE13712_STATICUp0.1591007994
GSE19018Down-0.7408273494
GSE19899_A1Up0.0284966626
GSE19899_A2Up0.2770987596
PubMed_21979375_A1Down-0.5595285505
PubMed_21979375_A2Up0.2050965155
GSE35957Down-1.0240134632
GSE36640Up0.3651445742
GSE54402Down-0.1162829556
GSE9593Up0.0801096315
GSE43922Up0.5837655498
GSE24585Up0.1182239625
GSE37065Up0.2817703345
GSE28863_A1Up1.4163059446
GSE28863_A2Up0.4713083737
GSE28863_A3Up0.4593800568
GSE28863_A4Up0.2983740249
GSE48662Up0.2070122416

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-34a-5pMIMAT0000255MIRT000074Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI20351093
hsa-miR-34a-5pMIMAT0000255MIRT000074Flow//Immunoblot//Luciferase reporter assay//Microarray//qRT-PCRFunctional MTI19398721
hsa-miR-21-5pMIMAT0000076MIRT000176Flow//Immunoblot//Luciferase reporter assay//Microarray//qRT-PCRFunctional MTI19398721
hsa-miR-21-5pMIMAT0000076MIRT000176Luciferase reporter assayFunctional MTI22618231
hsa-miR-21-5pMIMAT0000076MIRT000176MicroarrayFunctional MTI (Weak)18591254
hsa-miR-34b-3pMIMAT0004676MIRT006291Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI22113133
hsa-miR-200c-3pMIMAT0000617MIRT005457Immunohistochemistry//qRT-PCRFunctional MTI (Weak)21224848
hsa-miR-524-5pMIMAT0002849MIRT006891Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI22871495
hsa-miR-375MIMAT0000728MIRT019703MicroarrayFunctional MTI (Weak)20215506
hsa-miR-98-5pMIMAT0000096MIRT027545MicroarrayFunctional MTI (Weak)19088304
hsa-let-7b-5pMIMAT0000063MIRT051999CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-34a-5pMIMAT00002551hsa-miR-34a{Western blot}{overexpression by miRNA precursor transfection}20351093
hsa-miR-21-5pMIMAT0000076NAhsa-miR-2119398721
hsa-miR-200c-3pMIMAT00006171hsa-miR-200c{Western blot}{overexpression by miRNA mimics tranfection}21224847
hsa-miR-141-3pMIMAT00004321hsa-miR-141{Western blot}{overexpression by miRNA mimics tranfection}21224847
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 7 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26650241Deregulated expression of Notch1 and Jagged1 is observed in colorectal cancer
24950189Conversely, over-expression of Notch1 or Jagged1 prolonged the replicative lifespan of endothelial cells
24445253Mutations in SAMHD1 cause Aicardi-Goutieres syndrome (AGS), an inflammatory disorder that shares phenotypic similarity with systemic lupus erythematosus, including activation of antiviral type 1 interferon (IFN)
24445253To further define the pathomechanisms underlying autoimmunity in AGS due to SAMHD1 mutations, we investigated the physiological properties of SAMHD1
24445253RESULTS: We show that increased dNTP pools due to SAMHD1 deficiency cause genome instability in fibroblasts of patients with AGS
24175851We exposed AGS, HGC-27 and GES-1 gastric cancer cell lines to IFN-gamma and found significantly reduced colony formation ability
24164458We found that IGFBP5 (insulin-like growth factor binding protein 5), PLAT (plasminogen activator), SNAI2 (snail homolog 2), JAG1 (jagged 1), SPRY4 (Sprouty homolog 4), and CD44 were upregulated, whereas CFB (complement factor B), VCAM1 (vascular cell adhesion molecule 1), AQP1 (aquaporin 1), LOXL1 (lysyl oxidase-like 1), and RBPMS (RNA-binding protein with multiple splicing) were down- regulated in both radiation-damaged and old cells
23104211Xenograft analyses using p53-functional AGS or -dysfunctional SNU601 cells displayed statistically significant tumor growth retardation by silencing MKRN1, which was reversed under depletion of p14ARF (AGS cells, MKRN1 knockdown tumors vs MKRN1 and p14ARF knockdown tumors: 164
20132052A neural crest origin was confirmed by increased colony-forming efficiency (CFE) in the presence of Jagged 1 and the expression of a number of neural crest markers within the developing colonies by ICC and serially passaged clones by Western blotting
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