HCSGD entry for DRD5

1. General information

Official gene symbolDRD5
Entrez ID1816
Gene full namedopamine receptor D5
Other gene symbolsDBDR DRD1B DRD1L2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001588Dopamine neurotransmitter receptor activity, coupled via GsTASmolecular_function
GO:0001963Synaptic transmission, dopaminergicNASbiological_process
GO:0001975Response to amphetamineIEAbiological_process
GO:0001992Regulation of systemic arterial blood pressure by vasopressinIEAbiological_process
GO:0001994Norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressureIEAbiological_process
GO:0004952Dopamine neurotransmitter receptor activityIDAmolecular_function
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005887Integral component of plasma membraneNAS TAScellular_component
GO:0006874Cellular calcium ion homeostasisTASbiological_process
GO:0007189Adenylate cyclase-activating G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0007190Activation of adenylate cyclase activityTASbiological_process
GO:0007191Adenylate cyclase-activating dopamine receptor signaling pathwayIDAbiological_process
GO:0007268Synaptic transmissionNASbiological_process
GO:0008306Associative learningIEAbiological_process
GO:0010579Positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0031526Brush border membraneIEAcellular_component
GO:0033861Negative regulation of NAD(P)H oxidase activityIDAbiological_process
GO:0035240Dopamine bindingIDAmolecular_function
GO:0042060Wound healingIEAbiological_process
GO:0042220Response to cocaineIEAbiological_process
GO:0045762Positive regulation of adenylate cyclase activityIDA NASbiological_process
GO:0045776Negative regulation of blood pressureIEAbiological_process
GO:0045924Regulation of female receptivityIEAbiological_process
GO:0046960SensitizationIEAbiological_process
GO:0060158Phospholipase C-activating dopamine receptor signaling pathwayTASbiological_process
GO:0060292Long term synaptic depressionIEAbiological_process
GO:0071870Cellular response to catecholamine stimulusIDAbiological_process
GO:0072593Reactive oxygen species metabolic processIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.34437413090.90513607010.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0264251537
GSE13712_SHEARUp0.1203742589
GSE13712_STATICDown-0.0122349394
GSE19018Down-0.0175823492
GSE19899_A1Up0.0736104467
GSE19899_A2Up0.1920241638
PubMed_21979375_A1Down-0.1985765146
PubMed_21979375_A2Up0.0601992635
GSE35957Down-0.0265783406
GSE36640Up0.1191915846
GSE54402Down-0.0266218344
GSE9593Down-0.0709354851
GSE43922Up0.0818486999
GSE24585Down-0.0937665511
GSE37065Up0.0890542496
GSE28863_A1Down-0.0243584540
GSE28863_A2Down-0.0043732071
GSE28863_A3Up0.4923213457
GSE28863_A4Up0.0890246780
GSE48662Up0.2791726906

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

ZiprasidoneDB00246 APRD00540
RopiniroleDB00268 APRD00302
OlanzapineDB00334 APRD00138
LoxapineDB00408 APRD00574
LisurideDB00589 APRD00636
FenoldopamDB00800 APRD00969
CarphenazineDB01038 APRD00848
PergolideDB01186 APRD00663
QuetiapineDB01224 APRD00675
AripiprazoleDB01238 APRD00638
MethotrimeprazineDB01403 -
ZuclopenthixolDB01624 DB08919 | DB08920
RotigotineDB05271 -
OlanzapineDB00334 APRD00138
MirtazapineDB00370 APRD00685
LoxapineDB00408 APRD00574
CinnarizineDB00568 APRD00332
ErgotamineDB00696 APRD00677
MianserinDB06148 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017477MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.