HCSGD entry for DRD4

1. General information

Official gene symbolDRD4
Entrez ID1815
Gene full namedopamine receptor D4
Other gene symbolsD4DR
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000187Activation of MAPK activityIDAbiological_process
GO:0001591Dopamine neurotransmitter receptor activity, coupled via Gi/GoIDA ISSmolecular_function
GO:0001662Behavioral fear responseNASbiological_process
GO:0001963Synaptic transmission, dopaminergicIEAbiological_process
GO:0001975Response to amphetamineISSbiological_process
GO:0004952Dopamine neurotransmitter receptor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0005938Cell cortexIEAcellular_component
GO:0006874Cellular calcium ion homeostasisICbiological_process
GO:0007194Negative regulation of adenylate cyclase activityIDAbiological_process
GO:0007195Adenylate cyclase-inhibiting dopamine receptor signaling pathwayIDAbiological_process
GO:0007212Dopamine receptor signaling pathwayIDAbiological_process
GO:0007614Short-term memoryIEAbiological_process
GO:0007623Circadian rhythmIEAbiological_process
GO:0008144Drug bindingIDAmolecular_function
GO:0008344Adult locomotory behaviorISSbiological_process
GO:0008355Olfactory learningIEAbiological_process
GO:0009648PhotoperiodismIEAbiological_process
GO:0012506Vesicle membraneIEAcellular_component
GO:0015459Potassium channel regulator activityNASmolecular_function
GO:0016020MembraneIDAcellular_component
GO:0017124SH3 domain bindingIDAmolecular_function
GO:0030818Negative regulation of cAMP biosynthetic processIDAbiological_process
GO:0032417Positive regulation of sodium:hydrogen antiporter activityIDAbiological_process
GO:0033674Positive regulation of kinase activityIDAbiological_process
GO:0034776Response to histamineIDAbiological_process
GO:0035176Social behaviorNASbiological_process
GO:0035240Dopamine bindingIDAmolecular_function
GO:0042053Regulation of dopamine metabolic processISSbiological_process
GO:0042417Dopamine metabolic processICbiological_process
GO:0042596Fear responseISSbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043195Terminal boutonIEAcellular_component
GO:0043197Dendritic spineIEAcellular_component
GO:0046928Regulation of neurotransmitter secretionIEAbiological_process
GO:0048148Behavioral response to cocaineISSbiological_process
GO:0048149Behavioral response to ethanolTASbiological_process
GO:0048545Response to steroid hormoneIEAbiological_process
GO:0050482Arachidonic acid secretionIDAbiological_process
GO:0050709Negative regulation of protein secretionIDAbiological_process
GO:0050848Regulation of calcium-mediated signalingIEAbiological_process
GO:0051586Positive regulation of dopamine uptake involved in synaptic transmissionICbiological_process
GO:0060041Retina development in camera-type eyeIEAbiological_process
GO:0060080Regulation of inhibitory postsynaptic membrane potentialISSbiological_process
GO:0060406Positive regulation of penile erectionIEAbiological_process
GO:1901386Negative regulation of voltage-gated calcium channel activityIDAbiological_process
GO:2000463Positive regulation of excitatory postsynaptic membrane potentialIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.67661119640.47147446910.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1656751106
GSE13712_SHEARUp0.1629005938
GSE13712_STATICUp0.0019534791
GSE19018Down-0.1629363471
GSE19899_A1Down-0.1542780168
GSE19899_A2Up0.0100897254
PubMed_21979375_A1Up0.0144200067
PubMed_21979375_A2Down-0.3621335695
GSE35957Down-0.0835481939
GSE36640Up0.1058960924
GSE54402Down-0.0659016396
GSE9593Down-0.0586792200
GSE43922Up0.1255797161
GSE24585Up0.0518241702
GSE37065Down-0.0197153157
GSE28863_A1Down-0.1327890459
GSE28863_A2Up0.0219154068
GSE28863_A3Up0.4981072326
GSE28863_A4Up0.1435033056
GSE48662Up0.1687965096

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

ZiprasidoneDB00246 APRD00540
RopiniroleDB00268 APRD00302
OlanzapineDB00334 APRD00138
ClozapineDB00363 APRD00470
ThiethylperazineDB00372 APRD00323
LoxapineDB00408 APRD00574
RemoxiprideDB00409 APRD00316
AmoxapineDB00543 APRD00142
LisurideDB00589 APRD00636
RisperidoneDB00734 APRD00187
PropiomazineDB00777 APRD00339
PergolideDB01186 APRD00663
QuetiapineDB01224 APRD00675
AripiprazoleDB01238 APRD00638
PaliperidoneDB01267 -
MethotrimeprazineDB01403 -
FlibanserinDB04908 -
IloperidoneDB04946 -
RotigotineDB05271 -
SLV 308DB05280 -
AsenapineDB06216 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022474MicroarrayFunctional MTI (Weak)18668037
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.