HCSGD entry for DPYS

1. General information

Official gene symbolDPYS
Entrez ID1807
Gene full namedihydropyrimidinase
Other gene symbolsDHP DHPase
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002058Uracil bindingIEAmolecular_function
GO:0002059Thymine bindingIEAmolecular_function
GO:0004157Dihydropyrimidinase activityIDA IMP TASmolecular_function
GO:0005829CytosolISS TAScellular_component
GO:0006206Pyrimidine nucleobase metabolic processTASbiological_process
GO:0006208Pyrimidine nucleobase catabolic processIDAbiological_process
GO:0006210Thymine catabolic processISSbiological_process
GO:0006212Uracil catabolic processIDA IMPbiological_process
GO:0008270Zinc ion bindingNASmolecular_function
GO:0016597Amino acid bindingIEAmolecular_function
GO:0016810Hydrolase activity, acting on carbon-nitrogen (but not peptide) bondsIEAmolecular_function
GO:0019482Beta-alanine metabolic processIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046135Pyrimidine nucleoside catabolic processTASbiological_process
GO:0051219Phosphoprotein bindingIEAmolecular_function
GO:0051289Protein homotetramerizationISSbiological_process
GO:0055086Nucleobase-containing small molecule metabolic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.38292427720.89256788120.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2135763281
GSE13712_SHEARDown-0.0089997540
GSE13712_STATICDown-0.0484850078
GSE19018Up0.2232367284
GSE19899_A1Up0.1093822813
GSE19899_A2Up0.3648433195
PubMed_21979375_A1Down-0.1317339777
PubMed_21979375_A2Up0.0462473097
GSE35957Up0.0724879633
GSE36640Up0.1073478094
GSE54402Down-0.0489560204
GSE9593Down-0.0677048418
GSE43922Up0.0050151692
GSE24585Up0.0826690809
GSE37065Up0.0908936319
GSE28863_A1Up0.0882065794
GSE28863_A2Down-0.0529206535
GSE28863_A3Up0.0933456214
GSE28863_A4Up0.0039058248
GSE48662Up0.0574628938

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.