HCSGD entry for DPP4
1. General information
| Official gene symbol | DPP4 |
|---|---|
| Entrez ID | 1803 |
| Gene full name | dipeptidyl-peptidase 4 |
| Other gene symbols | ADABP ADCP2 CD26 DPPIV TP103 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001666 | Response to hypoxia | IDA | biological_process |
| GO:0002020 | Protease binding | IPI | molecular_function |
| GO:0004177 | Aminopeptidase activity | IEA | molecular_function |
| GO:0004252 | Serine-type endopeptidase activity | IEA | molecular_function |
| GO:0005102 | Receptor binding | IPI | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005765 | Lysosomal membrane | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0007155 | Cell adhesion | IEA | biological_process |
| GO:0008236 | Serine-type peptidase activity | IDA | molecular_function |
| GO:0008239 | Dipeptidyl-peptidase activity | IDA | molecular_function |
| GO:0008284 | Positive regulation of cell proliferation | IDA | biological_process |
| GO:0009986 | Cell surface | IDA | cellular_component |
| GO:0010716 | Negative regulation of extracellular matrix disassembly | IDA | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016324 | Apical plasma membrane | IDA | cellular_component |
| GO:0030027 | Lamellipodium | IDA | cellular_component |
| GO:0030139 | Endocytic vesicle | IDA | cellular_component |
| GO:0031258 | Lamellipodium membrane | IEA | cellular_component |
| GO:0031295 | T cell costimulation | IDA | biological_process |
| GO:0033632 | Regulation of cell-cell adhesion mediated by integrin | IDA | biological_process |
| GO:0042110 | T cell activation | IDA | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0042803 | Protein homodimerization activity | IPI | molecular_function |
| GO:0043542 | Endothelial cell migration | IDA | biological_process |
| GO:0045121 | Membrane raft | IEA | cellular_component |
| GO:0046581 | Intercellular canaliculus | IEA | cellular_component |
| GO:0070062 | Extracellular vesicular exosome | IDA | cellular_component |
| GO:0071438 | Invadopodium membrane | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0000117093 | 0.9692423616 | 0.0115777778 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.5540099762 |
| GSE13712_SHEAR | Up | 1.4727305315 |
| GSE13712_STATIC | Up | 0.7886836217 |
| GSE19018 | Down | -0.8995134478 |
| GSE19899_A1 | Up | 1.5916032489 |
| GSE19899_A2 | Up | 1.6513976507 |
| PubMed_21979375_A1 | Up | 2.5022471412 |
| PubMed_21979375_A2 | Up | 3.5553355468 |
| GSE35957 | Up | 2.8517286010 |
| GSE36640 | Up | 2.5151332889 |
| GSE54402 | Down | -0.0126862828 |
| GSE9593 | Up | 1.0441395241 |
| GSE43922 | Up | 1.0034295402 |
| GSE24585 | Up | 0.8470676604 |
| GSE37065 | Up | 1.0749956655 |
| GSE28863_A1 | Up | 1.0680674588 |
| GSE28863_A2 | Up | 2.3741726790 |
| GSE28863_A3 | Down | -0.5923085169 |
| GSE28863_A4 | Up | 0.2945812568 |
| GSE48662 | Down | -0.6257898653 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20448207 | Dipeptidyl-peptidase 4 (DPP-4) inhibition significantly increased GLP-1 levels in these animals and reduced senescence almost to lean animal levels |
| 20448207 | CONCLUSIONS: Dipeptidyl-peptidase 4 inhibition protects against vascular senescence in a diabetic rat model |
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