HCSGD entry for DOCK2

1. General information

Official gene symbolDOCK2
Entrez ID1794
Gene full namededicator of cytokinesis 2
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001766Membrane raft polarizationIEAbiological_process
GO:0001768Establishment of T cell polarityIEAbiological_process
GO:0001771Immunological synapse formationIEAbiological_process
GO:0002277Myeloid dendritic cell activation involved in immune responseIEA ISSbiological_process
GO:0005085Guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005829CytosolTAScellular_component
GO:0005856CytoskeletonIEAcellular_component
GO:0006935ChemotaxisIEAbiological_process
GO:0007010Cytoskeleton organizationIEAbiological_process
GO:0007264Small GTPase mediated signal transductionIEAbiological_process
GO:0012505Endomembrane systemIEAcellular_component
GO:0016020MembraneIEAcellular_component
GO:0016032Viral processTASbiological_process
GO:0030036Actin cytoskeleton organizationTASbiological_process
GO:0030675Rac GTPase activator activityIEAmolecular_function
GO:0030676Rac guanyl-nucleotide exchange factor activityIDAmolecular_function
GO:0032314Regulation of Rac GTPase activityIDAbiological_process
GO:0042608T cell receptor bindingIDAmolecular_function
GO:0044351MacropinocytosisIEA ISSbiological_process
GO:0045059Positive thymic T cell selectionIEAbiological_process
GO:0045060Negative thymic T cell selectionIEAbiological_process
GO:0046633Alpha-beta T cell proliferationIEAbiological_process
GO:0050690Regulation of defense response to virus by virusTASbiological_process
GO:0050766Positive regulation of phagocytosisIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.93271258310.26714084570.99999024730.9890025176

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1679649243
GSE13712_SHEARUp0.1302956788
GSE13712_STATICDown-0.0352468279
GSE19018Up0.0350688607
GSE19899_A1Down-0.0052095528
GSE19899_A2Down-0.0425439900
PubMed_21979375_A1Down-0.2415653702
PubMed_21979375_A2Down-0.2786414395
GSE35957Down-0.4183998868
GSE36640Down-0.0584532390
GSE54402Down-0.0428582504
GSE9593Down-0.0181743230
GSE43922Up0.0226337787
GSE24585Up0.0088048614
GSE37065Down-0.0662476035
GSE28863_A1Down-0.5445368870
GSE28863_A2Up0.1763188151
GSE28863_A3Down-0.1021747107
GSE28863_A4Up0.0411122889
GSE48662Down-0.3157928264

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.