HCSGD entry for DYNC1I1
1. General information
| Official gene symbol | DYNC1I1 |
|---|---|
| Entrez ID | 1780 |
| Gene full name | dynein, cytoplasmic 1, intermediate chain 1 |
| Other gene symbols | DNCI1 DNCIC1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000776 | Kinetochore | IDA | cellular_component |
| GO:0000777 | Condensed chromosome kinetochore | IEA | cellular_component |
| GO:0000922 | Spindle pole | IDA | cellular_component |
| GO:0003774 | Motor activity | TAS | molecular_function |
| GO:0003777 | Microtubule motor activity | ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005868 | Cytoplasmic dynein complex | IEA ISS | cellular_component |
| GO:0005874 | Microtubule | IEA | cellular_component |
| GO:0007018 | Microtubule-based movement | IEA | biological_process |
| GO:0008017 | Microtubule binding | ISS | molecular_function |
| GO:0008152 | Metabolic process | ISS TAS | biological_process |
| GO:0019886 | Antigen processing and presentation of exogenous peptide antigen via MHC class II | TAS | biological_process |
| GO:0031982 | Vesicle | IDA | cellular_component |
| GO:0047496 | Vesicle transport along microtubule | ISS | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | ISS | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1474987804 | 0.8120600243 | 0.7694283789 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1768240723 |
| GSE13712_SHEAR | Down | -0.1079358289 |
| GSE13712_STATIC | Down | -0.0748443668 |
| GSE19018 | Up | 0.2117411674 |
| GSE19899_A1 | Up | 0.0453947265 |
| GSE19899_A2 | Up | 0.0682537665 |
| PubMed_21979375_A1 | Down | -0.0859027413 |
| PubMed_21979375_A2 | Up | 0.1433202794 |
| GSE35957 | Up | 0.8394994131 |
| GSE36640 | Up | 0.1361203052 |
| GSE54402 | Up | 0.3276825172 |
| GSE9593 | Up | 0.3848823436 |
| GSE43922 | Up | 0.0138248351 |
| GSE24585 | Up | 0.5148132389 |
| GSE37065 | Down | -0.2831088038 |
| GSE28863_A1 | Down | -0.4531347984 |
| GSE28863_A2 | Up | 0.0216417093 |
| GSE28863_A3 | Down | -0.1047718838 |
| GSE28863_A4 | Up | 0.0249820009 |
| GSE48662 | Up | 0.3839891713 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT016726 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 11500918 | Among them is the DNCI1 gene encoding an intermediate chain 1 of the cytoplasmic dynein, a microtubule motor that plays a role in chromosome movement and organelle transport |
| 11500918 | The DNCI1 mRNA was also upregulated during in vitro aging of primary human fibroblasts |
| 11500918 | Cell growth arrest by serum starvation, contact inhibition, or gamma-irradiation did not induce the DNCI1 mRNA, suggesting its specific role in cellular senescence |
| 11500918 | The DNCI1 gene is on the long arm of chromosome 7 where tumor suppressor genes and a senescence-inducing gene for a group of immortal cell lines (complementation group D) are mapped |
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