HCSGD entry for DNASE2
1. General information
| Official gene symbol | DNASE2 |
|---|---|
| Entrez ID | 1777 |
| Gene full name | deoxyribonuclease II, lysosomal |
| Other gene symbols | DNASE2A DNL DNL2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000737 | DNA catabolic process, endonucleolytic | TAS | biological_process |
| GO:0003677 | DNA binding | TAS | molecular_function |
| GO:0004531 | Deoxyribonuclease II activity | IEA | molecular_function |
| GO:0005764 | Lysosome | IEA | cellular_component |
| GO:0006259 | DNA metabolic process | TAS | biological_process |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0030218 | Erythrocyte differentiation | IEA | biological_process |
| GO:0090305 | Nucleic acid phosphodiester bond hydrolysis | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4260425858 | 0.0483512936 | 0.9999902473 | 0.4116433560 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1383933575 |
| GSE13712_SHEAR | Down | -0.4935657113 |
| GSE13712_STATIC | Up | 0.0213712129 |
| GSE19018 | Up | 0.1678758192 |
| GSE19899_A1 | Down | -0.6362654362 |
| GSE19899_A2 | Down | -0.7256578190 |
| PubMed_21979375_A1 | Down | -0.0184340288 |
| PubMed_21979375_A2 | Down | -1.1043550193 |
| GSE35957 | Down | -0.0640316905 |
| GSE36640 | Up | 0.3743892496 |
| GSE54402 | Down | -0.4707784356 |
| GSE9593 | Up | 1.3769230338 |
| GSE43922 | Down | -0.3395519036 |
| GSE24585 | Up | 0.0838364802 |
| GSE37065 | Up | 0.1101329920 |
| GSE28863_A1 | Up | 0.0253062350 |
| GSE28863_A2 | Up | 0.0781361755 |
| GSE28863_A3 | Down | -0.7749777955 |
| GSE28863_A4 | Up | 0.0395070591 |
| GSE48662 | Up | 1.0175734308 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-320b | MIMAT0005792 | MIRT036213 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045041 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
