HCSGD entry for DNASE1L3
1. General information
| Official gene symbol | DNASE1L3 |
|---|---|
| Entrez ID | 1776 |
| Gene full name | deoxyribonuclease I-like 3 |
| Other gene symbols | DHP2 DNAS1L3 LSD SLEB16 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0004520 | Endodeoxyribonuclease activity | IEA | molecular_function |
| GO:0004536 | Deoxyribonuclease activity | TAS | molecular_function |
| GO:0005509 | Calcium ion binding | TAS | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006259 | DNA metabolic process | TAS | biological_process |
| GO:0006309 | Apoptotic DNA fragmentation | IEA | biological_process |
| GO:0010623 | Developmental programmed cell death | IEA | biological_process |
| GO:0016888 | Endodeoxyribonuclease activity, producing 5'-phosphomonoesters | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5148862847 | 0.6026383876 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0025048273 |
| GSE13712_SHEAR | Down | -0.4002246087 |
| GSE13712_STATIC | Down | -0.2343977994 |
| GSE19018 | Up | 0.3660498520 |
| GSE19899_A1 | Up | 0.1515589582 |
| GSE19899_A2 | Up | 0.0901290405 |
| PubMed_21979375_A1 | Down | -0.1908230762 |
| PubMed_21979375_A2 | Down | -0.0680391426 |
| GSE35957 | Down | -0.0017857497 |
| GSE36640 | Up | 0.0756316586 |
| GSE54402 | Up | 0.0399062742 |
| GSE9593 | Up | 0.0054006443 |
| GSE43922 | Up | 0.0135543425 |
| GSE24585 | Up | 0.5129141846 |
| GSE37065 | Up | 0.3007453998 |
| GSE28863_A1 | Down | -0.3200750461 |
| GSE28863_A2 | Down | -0.0937895865 |
| GSE28863_A3 | Up | 0.0061375399 |
| GSE28863_A4 | Down | -0.0279348285 |
| GSE48662 | Up | 0.1294224450 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT016727 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 8954124 | This structure-specific binding of RFC is supported by the observations that it binds to 3'-OH/5'-P ends in telomere repeats produced by DNase gamma, but not to those produced by 3'-P/5'-OH ends for DNase alpha |
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